Microwave-Assisted Synthesis of Pyrazinamide Derivatives: The Coupling Reaction of 3-Chloropyrazine-2-Carboxamide and Ring-Substituted Anilines

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10312035" target="_blank" >RIV/00216208:11160/15:10312035 - isvavai.cz</a>

Výsledek na webu

<a href="http://benthamscience.com/journals/current-organic-synthesis/volume/12/issue/2/page/189/" target="_blank" >http://benthamscience.com/journals/current-organic-synthesis/volume/12/issue/2/page/189/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1570179411999141106101501" target="_blank" >10.2174/1570179411999141106101501</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Microwave-Assisted Synthesis of Pyrazinamide Derivatives: The Coupling Reaction of 3-Chloropyrazine-2-Carboxamide and Ring-Substituted Anilines

Popis výsledku v původním jazyce

A new approach for aminodehalogenation reaction between 3-chloropyrazine-2-carboxamide and ring-substituted anilines is described. A series of 16 compounds (15 of them novel) derived from pyrazinamide have been synthesized successfully using the advantage of microwave-assisted reaction. The conditions for this aminodehalogenation reaction have been put to investigation to optimize the conversion, yield and time. The final methodology reduces the time needed for reaction from 24 hours using conventionalheating to 30 minutes under microwave irradiation and increases the yield. The synthetic procedure together with analytical data of all compounds is presented. Lipophilicity properties were calculated and experimentally determined.

Název v anglickém jazyce

Microwave-Assisted Synthesis of Pyrazinamide Derivatives: The Coupling Reaction of 3-Chloropyrazine-2-Carboxamide and Ring-Substituted Anilines

Popis výsledku anglicky

A new approach for aminodehalogenation reaction between 3-chloropyrazine-2-carboxamide and ring-substituted anilines is described. A series of 16 compounds (15 of them novel) derived from pyrazinamide have been synthesized successfully using the advantage of microwave-assisted reaction. The conditions for this aminodehalogenation reaction have been put to investigation to optimize the conversion, yield and time. The final methodology reduces the time needed for reaction from 24 hours using conventionalheating to 30 minutes under microwave irradiation and increases the yield. The synthetic procedure together with analytical data of all compounds is presented. Lipophilicity properties were calculated and experimentally determined.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Organic Synthesis

ISSN

1570-1794

e-ISSN

—

Svazek periodika

12

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

AE - Spojené arabské emiráty

Počet stran výsledku

8

Strana od-do

189-196

Kód UT WoS článku

000350751700009

EID výsledku v databázi Scopus

2-s2.0-84931031012