Cardiovascular Effects of Coumarins Besides their Antioxidant Activity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10312164" target="_blank" >RIV/00216208:11160/15:10312164 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/15:33157021

Výsledek na webu

<a href="http://benthamscience.com/journals/current-topics-in-medicinal-chemistry/volume/15/issue/9/page/830/" target="_blank" >http://benthamscience.com/journals/current-topics-in-medicinal-chemistry/volume/15/issue/9/page/830/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1568026615666150220112437" target="_blank" >10.2174/1568026615666150220112437</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cardiovascular Effects of Coumarins Besides their Antioxidant Activity

Popis výsledku v původním jazyce

Coumarins are a large group of substances, primarily of plant origin. Like their more intensively examined congeners flavonoids, many of them are antioxidants. Although such properties may be advantageous in cardiovascular diseases, it has been shown that coumarins exhibit direct effects on the cardiovascular system which are not based on antioxidant activity. The most common example is the well-known drug warfarin, a synthetic compound derived from natural dicoumarol. Moreover, other coumarins have been shown to possess antiplatelet and vasodilatory potential. Interestingly, the former effect may be mediated by the inhibition of various pathways leading to platelet aggregation, their differing effects on those pathways being due to structural differences between the various coumarins. Conversely, their vasodilatory potential is linked in the majority of cases to the inhibition of increases in intracellular calcium concentration in vascular smooth muscle cells, and in several coumarins

Název v anglickém jazyce

Cardiovascular Effects of Coumarins Besides their Antioxidant Activity

Popis výsledku anglicky

Coumarins are a large group of substances, primarily of plant origin. Like their more intensively examined congeners flavonoids, many of them are antioxidants. Although such properties may be advantageous in cardiovascular diseases, it has been shown that coumarins exhibit direct effects on the cardiovascular system which are not based on antioxidant activity. The most common example is the well-known drug warfarin, a synthetic compound derived from natural dicoumarol. Moreover, other coumarins have been shown to possess antiplatelet and vasodilatory potential. Interestingly, the former effect may be mediated by the inhibition of various pathways leading to platelet aggregation, their differing effects on those pathways being due to structural differences between the various coumarins. Conversely, their vasodilatory potential is linked in the majority of cases to the inhibition of increases in intracellular calcium concentration in vascular smooth muscle cells, and in several coumarins

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/GBP303%2F12%2FG163" target="_blank" >GBP303/12/G163: Centrum interakcí potravních doplňků s léčivy a nutrigenetiky</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Topics in Medicinal Chemistry

ISSN

1568-0266

e-ISSN

—

Svazek periodika

15

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

AE - Spojené arabské emiráty

Počet stran výsledku

20

Strana od-do

830-849

Kód UT WoS článku

000351855200003

EID výsledku v databázi Scopus

2-s2.0-84928894220