Antifungal and Antibacterial Activity of Extracts and Alkaloids of Selected Amaryllidaceae Species

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10312362" target="_blank" >RIV/00216208:11160/15:10312362 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60460709:41210/15:68008 RIV/60460709:41340/15:68008

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Antifungal and Antibacterial Activity of Extracts and Alkaloids of Selected Amaryllidaceae Species

Popis výsledku v původním jazyce

Alkaloidal extracts of six selected species of Amaryllidaceae were studied with respect to their antibacterial and anti-yeast activity and their alkaloidal fingerprint. Twenty-five alkaloids were determined by GC/MS, and sixteen of them identified from their mass spectra, retention times and retention indexes. In the antimicrobial assay, Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus were used, along with isolates of the human pathogenic yeasts Candida albicans, C. glabrata, C. dubliniensis and Lodderomyces elongiosporus. The six extracts, together with 19 Amaryllidaceae alkaloids isolated in our laboratory, showed almost no inhibitory activity against the bacteria tested. However, promising anti-yeast properties were detected;the most potent activity was shown by lycorine, which inhibited C. dubliniensis with a MIC of 32 mu g/mL, C. albicans and L. elongiosporus, both with MICs of 64 mu g/mL, followed by caranine inhibiting C. dubliniensis with a MIC of 128 mu

Název v anglickém jazyce

Antifungal and Antibacterial Activity of Extracts and Alkaloids of Selected Amaryllidaceae Species

Popis výsledku anglicky

Alkaloidal extracts of six selected species of Amaryllidaceae were studied with respect to their antibacterial and anti-yeast activity and their alkaloidal fingerprint. Twenty-five alkaloids were determined by GC/MS, and sixteen of them identified from their mass spectra, retention times and retention indexes. In the antimicrobial assay, Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus were used, along with isolates of the human pathogenic yeasts Candida albicans, C. glabrata, C. dubliniensis and Lodderomyces elongiosporus. The six extracts, together with 19 Amaryllidaceae alkaloids isolated in our laboratory, showed almost no inhibitory activity against the bacteria tested. However, promising anti-yeast properties were detected;the most potent activity was shown by lycorine, which inhibited C. dubliniensis with a MIC of 32 mu g/mL, C. albicans and L. elongiosporus, both with MICs of 64 mu g/mL, followed by caranine inhibiting C. dubliniensis with a MIC of 128 mu

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Natural Product Communications

ISSN

1934-578X

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

1537-1540

Kód UT WoS článku

000361868900012

EID výsledku v databázi Scopus

2-s2.0-84954596731