Indole-2-carboxamide derivatives: a patent evaluation of WO2015036412A1
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F15%3A10317175" target="_blank" >RIV/00216208:11160/15:10317175 - isvavai.cz</a>
Výsledek na webu
<a href="http://www.tandfonline.com/doi/full/10.1517/13543776.2015.1101066" target="_blank" >http://www.tandfonline.com/doi/full/10.1517/13543776.2015.1101066</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1517/13543776.2015.1101066" target="_blank" >10.1517/13543776.2015.1101066</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Indole-2-carboxamide derivatives: a patent evaluation of WO2015036412A1
Popis výsledku v původním jazyce
Introduction: Hippocampal neurogenesis in adults is a new and attractive target for the treatment and prevention of neurodegenerative and neuro-psychiatric diseases. Recently, neurogenesis stimulating activity was observed in some of the commonly used small molecule drugs such as antidepressants and atypical antipsychotics. Stimulation of neurogenesis is attractive mainly due to its wide scope of application, ranging from depressions, schizophrenia, dementia, Parkinson's and Alzheimer's Disease to various brain injuries.Areas covered: New compounds based on 7-phenyl or 7-pyridinyl-1H-indole-2-carboxamide showed interesting neural stem cell proliferation inducing activity in vitro and were claimed as potential therapeutics for various neurodegenerativeand neuropsychiatric diseases as well as brain injuries. The potential of the presented compounds is evaluated with respect to other small molecule neurogenesis inducers in literature.Expert opinion: Nanomolar in vitro activities of prese
Název v anglickém jazyce
Indole-2-carboxamide derivatives: a patent evaluation of WO2015036412A1
Popis výsledku anglicky
Introduction: Hippocampal neurogenesis in adults is a new and attractive target for the treatment and prevention of neurodegenerative and neuro-psychiatric diseases. Recently, neurogenesis stimulating activity was observed in some of the commonly used small molecule drugs such as antidepressants and atypical antipsychotics. Stimulation of neurogenesis is attractive mainly due to its wide scope of application, ranging from depressions, schizophrenia, dementia, Parkinson's and Alzheimer's Disease to various brain injuries.Areas covered: New compounds based on 7-phenyl or 7-pyridinyl-1H-indole-2-carboxamide showed interesting neural stem cell proliferation inducing activity in vitro and were claimed as potential therapeutics for various neurodegenerativeand neuropsychiatric diseases as well as brain injuries. The potential of the presented compounds is evaluated with respect to other small molecule neurogenesis inducers in literature.Expert opinion: Nanomolar in vitro activities of prese
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
—
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Expert Opinion on Therapeutic Patents
ISSN
1354-3776
e-ISSN
—
Svazek periodika
25
Číslo periodika v rámci svazku
12
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
8
Strana od-do
1487-1494
Kód UT WoS článku
000366528500003
EID výsledku v databázi Scopus
2-s2.0-84949764924