Allergy-Like Immediate Reactions with Herbal Medicines: A Retrospective Study Using Data from VigiBase(R)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F16%3A10328296" target="_blank" >RIV/00216208:11160/16:10328296 - isvavai.cz</a>

Výsledek na webu

<a href="http://link.springer.com/article/10.1007/s40264-016-0401-5" target="_blank" >http://link.springer.com/article/10.1007/s40264-016-0401-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s40264-016-0401-5" target="_blank" >10.1007/s40264-016-0401-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Allergy-Like Immediate Reactions with Herbal Medicines: A Retrospective Study Using Data from VigiBase(R)

Popis výsledku v původním jazyce

Introduction Herbal medicines are used worldwide and with an increasing popularity in Western countries. Although often perceived as 'naturally safe', herbals may cause severe adverse drug reactions (ADRs), with immediate allergic reactions being particularly life threatening. Objectives The aim of this study was to analyse immediate allergy-like ADRs to herbals documented in VigiBase(R), the WHO international pharmacovigilance database. Methods The documentation of all suspected ADRs in association with herbal exposure reported to VigiBase(R) from 1969 to August 2014 was retrieved. Among all reports in which WHO-ART reaction terms were indicative of acute allergic reactions, those classified as 'suspect' with a documented causality assessment and latency time of <= 1 day were selected. For the most frequent specific herbal-ADR combinations, the information component (IC) as a measure of disproportionality based on Bayesian statistics was calculated. Results We identified 757 reports out of 1039 ADRs. Products with mixed herbals (36.0 %) as well as those administered orally (63.2 %) were predominant. The most frequent reactions were urticaria and rash (49.2 %). Anaphylactic reactions accounted for 9.5 %. Disproportionally frequent reporting of mouth edema (IC = 1.81) and anaphylactic reactions (IC = 1.24) to Phleum pretense were noted. Conclusion Our findings indicate that herbal medicines for oral use carry a risk of causing immediate allergy-like ADRs. Studies using the Vigibase(R) database can identify specific combinations of particular herbs and adverse reactions. Healthcare professionals and patients should be aware of these risks and report any serious adverse experiences.

Název v anglickém jazyce

Allergy-Like Immediate Reactions with Herbal Medicines: A Retrospective Study Using Data from VigiBase(R)

Popis výsledku anglicky

Introduction Herbal medicines are used worldwide and with an increasing popularity in Western countries. Although often perceived as 'naturally safe', herbals may cause severe adverse drug reactions (ADRs), with immediate allergic reactions being particularly life threatening. Objectives The aim of this study was to analyse immediate allergy-like ADRs to herbals documented in VigiBase(R), the WHO international pharmacovigilance database. Methods The documentation of all suspected ADRs in association with herbal exposure reported to VigiBase(R) from 1969 to August 2014 was retrieved. Among all reports in which WHO-ART reaction terms were indicative of acute allergic reactions, those classified as 'suspect' with a documented causality assessment and latency time of <= 1 day were selected. For the most frequent specific herbal-ADR combinations, the information component (IC) as a measure of disproportionality based on Bayesian statistics was calculated. Results We identified 757 reports out of 1039 ADRs. Products with mixed herbals (36.0 %) as well as those administered orally (63.2 %) were predominant. The most frequent reactions were urticaria and rash (49.2 %). Anaphylactic reactions accounted for 9.5 %. Disproportionally frequent reporting of mouth edema (IC = 1.81) and anaphylactic reactions (IC = 1.24) to Phleum pretense were noted. Conclusion Our findings indicate that herbal medicines for oral use carry a risk of causing immediate allergy-like ADRs. Studies using the Vigibase(R) database can identify specific combinations of particular herbs and adverse reactions. Healthcare professionals and patients should be aware of these risks and report any serious adverse experiences.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FQ - Veřejné zdravotnictví, sociální lékařství

OECD FORD obor

—

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Drug Safety

ISSN

0114-5916

e-ISSN

—

Svazek periodika

39

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

NZ - Nový Zéland

Počet stran výsledku

10

Strana od-do

455-464

Kód UT WoS článku

000374330200009

EID výsledku v databázi Scopus

2-s2.0-84959473155