Ceramides in the skin barrier

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F17%3A10371812" target="_blank" >RIV/00216208:11160/17:10371812 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.degruyter.com/view/j/afpuc.2017.64.issue-2/afpuc-2017-0004/afpuc-2017-0004.xml" target="_blank" >http://www.degruyter.com/view/j/afpuc.2017.64.issue-2/afpuc-2017-0004/afpuc-2017-0004.xml</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/afpuc-2017-0004" target="_blank" >10.1515/afpuc-2017-0004</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ceramides in the skin barrier

Popis výsledku v původním jazyce

The skin barrier, which is essential for human survival on dry land, is located in the uppermost skin layer, the stratum corneum. The stratum corneum consists of corneocytes surrounded by multilamellar lipid membranes that prevent excessive water loss from the body and entrance of undesired substances from the environment. To ensure this protective function, the composition and organization of the lipid membranes is highly specialized. The major skin barrier lipids are ceramides, fatty acids and cholesterol in an approximately equimolar ratio. With hundreds of molecular species of ceramide, skin barrier lipids are a highly complex mixture that complicate the investigation of its behaviour. In this minireview, the structures of the major skin barrier lipids, formation of the stratum corneum lipid membranes and their molecular organization are described.

Název v anglickém jazyce

Ceramides in the skin barrier

Popis výsledku anglicky

The skin barrier, which is essential for human survival on dry land, is located in the uppermost skin layer, the stratum corneum. The stratum corneum consists of corneocytes surrounded by multilamellar lipid membranes that prevent excessive water loss from the body and entrance of undesired substances from the environment. To ensure this protective function, the composition and organization of the lipid membranes is highly specialized. The major skin barrier lipids are ceramides, fatty acids and cholesterol in an approximately equimolar ratio. With hundreds of molecular species of ceramide, skin barrier lipids are a highly complex mixture that complicate the investigation of its behaviour. In this minireview, the structures of the major skin barrier lipids, formation of the stratum corneum lipid membranes and their molecular organization are described.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/GC16-25687J" target="_blank" >GC16-25687J: Vztahy mezi zánětlivými procesy a bariérovými lipidy u onemocnění kůže</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Pharmaceutical Journal

ISSN

2453-6725

e-ISSN

—

Svazek periodika

64

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

28-35

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85038365915