Interaction of isolated silymarin flavonolignans with iron and copper

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F18%3A10381908" target="_blank" >RIV/00216208:11160/18:10381908 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388971:_____/18:00497478

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S016201341830285X" target="_blank" >http://www.sciencedirect.com/science/article/pii/S016201341830285X</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jinorgbio.2018.09.006" target="_blank" >10.1016/j.jinorgbio.2018.09.006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Interaction of isolated silymarin flavonolignans with iron and copper

Popis výsledku v původním jazyce

Silymarin (the standardized extract of mainly flavonolignans from silybum marianum) is approved for the adjuvant therapy of alcoholic liver disease and is also sold as an over the counter drug for miscelaneous purposes. Hence, the exposition of humans to these flavonolignans is not negligible. In this study we tested the interaction of isolated optically pure flavonolignans from silymarin with iron and copper which is relevant in the gastrointestinal tract due to low biovailability of these compounds. Only 2,3-dehydrosilybin was found to be a potent or moderately active iron and copper chelator. Silybin A, silybin B and silychristin A were less potent or inactive chelators. Both 2,3-dehydrosilybin enantiomers (A and B) were equally active iron and copper chelators, and the preferred stoichiometries were mainly 2:1 and 3:1 (2,3-dehydrosilybin:metal). Additional experiments showed that silychristin was the most potent iron and copper reductant.

Název v anglickém jazyce

Interaction of isolated silymarin flavonolignans with iron and copper

Popis výsledku anglicky

Silymarin (the standardized extract of mainly flavonolignans from silybum marianum) is approved for the adjuvant therapy of alcoholic liver disease and is also sold as an over the counter drug for miscelaneous purposes. Hence, the exposition of humans to these flavonolignans is not negligible. In this study we tested the interaction of isolated optically pure flavonolignans from silymarin with iron and copper which is relevant in the gastrointestinal tract due to low biovailability of these compounds. Only 2,3-dehydrosilybin was found to be a potent or moderately active iron and copper chelator. Silybin A, silybin B and silychristin A were less potent or inactive chelators. Both 2,3-dehydrosilybin enantiomers (A and B) were equally active iron and copper chelators, and the preferred stoichiometries were mainly 2:1 and 3:1 (2,3-dehydrosilybin:metal). Additional experiments showed that silychristin was the most potent iron and copper reductant.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/GA18-00121S" target="_blank" >GA18-00121S: Role opticky čistých flavonolignanů v kardiovaskulárních účincích silymarinu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Inorganic Biochemistry

ISSN

0162-0134

e-ISSN

—

Svazek periodika

189

Číslo periodika v rámci svazku

December

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

115-123

Kód UT WoS článku

000449036800012

EID výsledku v databázi Scopus

2-s2.0-85053810495