Fractal Aspects of Static and Dynamic Flow Properties of Pharmaceutical Excipients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F18%3A10382169" target="_blank" >RIV/00216208:11160/18:10382169 - isvavai.cz</a>

Výsledek na webu

<a href="http://link.springer.com/article/10.1007/s12247-017-9302-0" target="_blank" >http://link.springer.com/article/10.1007/s12247-017-9302-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12247-017-9302-0" target="_blank" >10.1007/s12247-017-9302-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Fractal Aspects of Static and Dynamic Flow Properties of Pharmaceutical Excipients

Popis výsledku v původním jazyce

Characterisation of powder flow is important for pharmaceutical processing and manufacturing. This work aims at a better understanding of how fractal particle and bulk properties affect the static and dynamic flow of excipients. Traditional methods of flowability testing, e.g. the angle of repose or the flow through an orifice, were complemented by avalanching in a rotational drum. Dynamic image analysis provided a fractal contour line dimension of the powder bulk in the drum (bD(F)). This was compared to the contour line fractal dimension of particles (pD(F)) as obtained from the box-counting method. Avalanche testing was able to measure also cohesive materials that were otherwise difficult or not measurable at all using the classical methods. The values of the avalanche energy were in good agreement with the different flow properties of the samples. These flow properties showed good correlations with bD(F) in that poor flow properties were associated with a more rugged contour line of the bulk and hence higher bD(F). Interestingly, there was no correlation observed between pD(F) and bD(F), which may suggest that a distinct bulk structure typically emerges from the particles under dynamic flow. Future research should further clarify how fractal powder aspects affect pharmaceutical manufacturing processes.

Název v anglickém jazyce

Fractal Aspects of Static and Dynamic Flow Properties of Pharmaceutical Excipients

Popis výsledku anglicky

Characterisation of powder flow is important for pharmaceutical processing and manufacturing. This work aims at a better understanding of how fractal particle and bulk properties affect the static and dynamic flow of excipients. Traditional methods of flowability testing, e.g. the angle of repose or the flow through an orifice, were complemented by avalanching in a rotational drum. Dynamic image analysis provided a fractal contour line dimension of the powder bulk in the drum (bD(F)). This was compared to the contour line fractal dimension of particles (pD(F)) as obtained from the box-counting method. Avalanche testing was able to measure also cohesive materials that were otherwise difficult or not measurable at all using the classical methods. The values of the avalanche energy were in good agreement with the different flow properties of the samples. These flow properties showed good correlations with bD(F) in that poor flow properties were associated with a more rugged contour line of the bulk and hence higher bD(F). Interestingly, there was no correlation observed between pD(F) and bD(F), which may suggest that a distinct bulk structure typically emerges from the particles under dynamic flow. Future research should further clarify how fractal powder aspects affect pharmaceutical manufacturing processes.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Pharmaceutical Innovation

ISSN

1872-5120

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

15-26

Kód UT WoS článku

000425309900002

EID výsledku v databázi Scopus

2-s2.0-85034756369