Sesquiterpenes alpha-humulene and beta-caryophyllene oxide enhance the efficacy of 5-fluorouracil and oxaliplatin in colon cancer cells
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F19%3A10408259" target="_blank" >RIV/00216208:11160/19:10408259 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11150/19:10408259
Výsledek na webu
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=UOepGrlJ65" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=UOepGrlJ65</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/acph-2019-0003" target="_blank" >10.2478/acph-2019-0003</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Sesquiterpenes alpha-humulene and beta-caryophyllene oxide enhance the efficacy of 5-fluorouracil and oxaliplatin in colon cancer cells
Popis výsledku v původním jazyce
The present study is designed to find out if sesquiterpenes, alpha-humulene (HUM), valencene (VAL), beta-caryphylleneoxide (CAO) and trans-nerolidol (NER), are able to improve the antiproliferative effect of classical cytostatic drugs, 5-fluorouracil (FU) and oxaliplatin (1,2-diaminocyclohexa-neoxalato-platinum, OxPt), in colon cancer cell lines Caco-2 and SW-620. In addition, the possible mechanisms of sesquiterpene action are studied. The results show significant ability of HUM and especially of CAO to enhance the antiproliferative effects of FU and OxPt in cancer cell lines Caco-2 and SW-620. On the other hand, VAL and NER are ineffective. The action of CAO could be partly based on its ability to disrupt the mitochondrial membrane potential and to activate initiator caspases, but other mechanisms are probably also involved. Based on these results, CAO seems to have the potential for combination therapy of colon cancers and deserves further study.
Název v anglickém jazyce
Sesquiterpenes alpha-humulene and beta-caryophyllene oxide enhance the efficacy of 5-fluorouracil and oxaliplatin in colon cancer cells
Popis výsledku anglicky
The present study is designed to find out if sesquiterpenes, alpha-humulene (HUM), valencene (VAL), beta-caryphylleneoxide (CAO) and trans-nerolidol (NER), are able to improve the antiproliferative effect of classical cytostatic drugs, 5-fluorouracil (FU) and oxaliplatin (1,2-diaminocyclohexa-neoxalato-platinum, OxPt), in colon cancer cell lines Caco-2 and SW-620. In addition, the possible mechanisms of sesquiterpene action are studied. The results show significant ability of HUM and especially of CAO to enhance the antiproliferative effects of FU and OxPt in cancer cell lines Caco-2 and SW-620. On the other hand, VAL and NER are ineffective. The action of CAO could be partly based on its ability to disrupt the mitochondrial membrane potential and to activate initiator caspases, but other mechanisms are probably also involved. Based on these results, CAO seems to have the potential for combination therapy of colon cancers and deserves further study.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30104 - Pharmacology and pharmacy
Návaznosti výsledku
Projekt
<a href="/cs/project/GBP303%2F12%2FG163" target="_blank" >GBP303/12/G163: Centrum interakcí potravních doplňků s léčivy a nutrigenetiky</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Acta Pharmaceutica
ISSN
1330-0075
e-ISSN
—
Svazek periodika
69
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
HR - Chorvatská republika
Počet stran výsledku
8
Strana od-do
121-128
Kód UT WoS článku
000452538800010
EID výsledku v databázi Scopus
2-s2.0-85058819383