Influence of cationic, anionic or non-charged substituents on photodynamic activity of water-soluble zinc (aza)phthalocyanines

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F19%3A10409915" target="_blank" >RIV/00216208:11160/19:10409915 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.spiedigitallibrary.org/conference-proceedings-of-spie/11070/110709M/Influence-of-cationic-anionic-or-non-charged-substituents-on-photodynamic/10.1117/12.2525591.full" target="_blank" >http://www.spiedigitallibrary.org/conference-proceedings-of-spie/11070/110709M/Influence-of-cationic-anionic-or-non-charged-substituents-on-photodynamic/10.1117/12.2525591.full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1117/12.2525591" target="_blank" >10.1117/12.2525591</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Influence of cationic, anionic or non-charged substituents on photodynamic activity of water-soluble zinc (aza)phthalocyanines

Popis výsledku v původním jazyce

Solubility of (aza)phthalocyanines ((Aza)Pc) in water is very limited due to their flat aromatic core that makes them prone to aggregation. Stacking of (Aza)Pc cores (forming dimers or higher-order aggregates) leads to quenching of their excited states - fluorescence and 1O2 production [1]. Several approaches to improve the solubility have been described, but truly non aggregating water-soluble (Aza)Pcs are still scarce [2-7]. Here we present a series of novel water-soluble hydrophilic and amphiphilic zinc (Aza)Pcs with differently charged (cationic and anionic) as well as non-charged peripheral substituents. These compounds were directly compared to several clinically approved photosensitizers (PSs; verteporfin, temoporfin, Photosens, methylene blue and protoporphyrin IX - a photodynamically active product of a prodrug 5-aminolevulinic acid).

Název v anglickém jazyce

Influence of cationic, anionic or non-charged substituents on photodynamic activity of water-soluble zinc (aza)phthalocyanines

Popis výsledku anglicky

Solubility of (aza)phthalocyanines ((Aza)Pc) in water is very limited due to their flat aromatic core that makes them prone to aggregation. Stacking of (Aza)Pc cores (forming dimers or higher-order aggregates) leads to quenching of their excited states - fluorescence and 1O2 production [1]. Several approaches to improve the solubility have been described, but truly non aggregating water-soluble (Aza)Pcs are still scarce [2-7]. Here we present a series of novel water-soluble hydrophilic and amphiphilic zinc (Aza)Pcs with differently charged (cationic and anionic) as well as non-charged peripheral substituents. These compounds were directly compared to several clinically approved photosensitizers (PSs; verteporfin, temoporfin, Photosens, methylene blue and protoporphyrin IX - a photodynamically active product of a prodrug 5-aminolevulinic acid).

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

17th International Photodynamic Association World Congress

ISBN

978-1-5106-2833-5

ISSN

0277-786X

e-ISSN

1996-756X

Počet stran výsledku

4

Strana od-do

4

Název nakladatele

Society of Photo-Optical Instrumentation Engineers

Místo vydání

Bellingham

Místo konání akce

Cambridge

Datum konání akce

28. 6. 2019

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000511105600065