A Mixture of Phenolic Metabolites of Quercetin Can Decrease Elevated Blood Pressure of Spontaneously Hypertensive Rats Even in Low Doses

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F20%3A10416951" target="_blank" >RIV/00216208:11160/20:10416951 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=LApu30ceMk" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=LApu30ceMk</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/nu12010213" target="_blank" >10.3390/nu12010213</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A Mixture of Phenolic Metabolites of Quercetin Can Decrease Elevated Blood Pressure of Spontaneously Hypertensive Rats Even in Low Doses

Popis výsledku v původním jazyce

Quercetin has been shown to decrease arterial blood pressure when given orally. Its has however low bioavailability. Hence its metabolites could rather be responsible for this effect. In this study, we have tested three combinations of colonic metabolites of quercetin, 3,4-dihydroxyphenylacetic acid (DHPA), 4-methylcatechol (4MC), and 3-(3-hydroxyphenyl)propionic acid (3HPPA). The effect of DHPA and 4MC was mild and very short-termed. A combination of DHPA with 3HPPA caused more pronounced effects, which were also rather short-lived. The last combination of 3HPPA and 4MC caused a long-lasting effect. We suppose that certain combinations of quercetin metabolites have a more profound antihypertensive effect than single metabolites.

Název v anglickém jazyce

A Mixture of Phenolic Metabolites of Quercetin Can Decrease Elevated Blood Pressure of Spontaneously Hypertensive Rats Even in Low Doses

Popis výsledku anglicky

Quercetin has been shown to decrease arterial blood pressure when given orally. Its has however low bioavailability. Hence its metabolites could rather be responsible for this effect. In this study, we have tested three combinations of colonic metabolites of quercetin, 3,4-dihydroxyphenylacetic acid (DHPA), 4-methylcatechol (4MC), and 3-(3-hydroxyphenyl)propionic acid (3HPPA). The effect of DHPA and 4MC was mild and very short-termed. A combination of DHPA with 3HPPA caused more pronounced effects, which were also rather short-lived. The last combination of 3HPPA and 4MC caused a long-lasting effect. We suppose that certain combinations of quercetin metabolites have a more profound antihypertensive effect than single metabolites.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nutrients

ISSN

2072-6643

e-ISSN

—

Svazek periodika

12

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

6

Strana od-do

213

Kód UT WoS článku

000516825500213

EID výsledku v databázi Scopus

2-s2.0-85078034950