Predicting the Angle of Internal Friction from Simple Dynamic Consolidation Using Lactose Grades as Model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F20%3A10417797" target="_blank" >RIV/00216208:11160/20:10417797 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26310/20:PU139702

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=RxFYmvrSf9" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=RxFYmvrSf9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12247-019-09387-3" target="_blank" >10.1007/s12247-019-09387-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Predicting the Angle of Internal Friction from Simple Dynamic Consolidation Using Lactose Grades as Model

Popis výsledku v původním jazyce

Purpose Powder flow and packing behavior are among other factors determined by particle friction, which is traditionally measured in shear cells as the angle of internal friction (AIF). Considering that an AIF at a normal stress should be comparable to friction during tapping consolidation, this work aims at whether dynamic consolidation under gravity can be used to estimate an AIF. Methods Powder consolidation by controlled tapping was studied for seven commercially available types of lactose. A porosity factor was determined, and values were compared with the AIF obtained from Jenike shear cell measurements. Results Plotting porosity factor vs. number of applied taps provided an estimated angle of internal friction (AIF(E)) that was obtained from the slope of a linear relationship. A significant linear correlation (r = 0.825; p = 0.0223) was evidenced between AIF(E) and those AIF(J) estimated from linearized yield locus measurements of using the Jenike shear cell. Conclusions The good linear correlation between the angle of internal friction estimated from dynamic powder consolidation and the internal friction obtained by a shear cell is of high practical relevance. The latter shear cell behavior is only occasionally studied in the pharmaceutical industry, whereas dynamic powder tapping is a standard analysis.

Název v anglickém jazyce

Predicting the Angle of Internal Friction from Simple Dynamic Consolidation Using Lactose Grades as Model

Popis výsledku anglicky

Purpose Powder flow and packing behavior are among other factors determined by particle friction, which is traditionally measured in shear cells as the angle of internal friction (AIF). Considering that an AIF at a normal stress should be comparable to friction during tapping consolidation, this work aims at whether dynamic consolidation under gravity can be used to estimate an AIF. Methods Powder consolidation by controlled tapping was studied for seven commercially available types of lactose. A porosity factor was determined, and values were compared with the AIF obtained from Jenike shear cell measurements. Results Plotting porosity factor vs. number of applied taps provided an estimated angle of internal friction (AIF(E)) that was obtained from the slope of a linear relationship. A significant linear correlation (r = 0.825; p = 0.0223) was evidenced between AIF(E) and those AIF(J) estimated from linearized yield locus measurements of using the Jenike shear cell. Conclusions The good linear correlation between the angle of internal friction estimated from dynamic powder consolidation and the internal friction obtained by a shear cell is of high practical relevance. The latter shear cell behavior is only occasionally studied in the pharmaceutical industry, whereas dynamic powder tapping is a standard analysis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/LO1211" target="_blank" >LO1211: Centrum materiálového výzkumu na FCH VUT v Brně - udržitelnost a rozvoj</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Pharmaceutical Innovation

ISSN

1872-5120

e-ISSN

—

Svazek periodika

15

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

380-391

Kód UT WoS článku

000560488800009

EID výsledku v databázi Scopus

2-s2.0-85073808220