Inhibitory effects of polyphenols and their colonic metabolites on CYP2D6 enzyme using two different substrates

Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F20%3A10417877" target="_blank" >RIV/00216208:11160/20:10417877 - isvavai.cz</a>
Výsledek na webu
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=T9cHV4oD6k" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=T9cHV4oD6k</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.biopha.2020.110732" target="_blank" >10.1016/j.biopha.2020.110732</a>

Jazyk výsledku
angličtina
Název v původním jazyce
Inhibitory effects of polyphenols and their colonic metabolites on CYP2D6 enzyme using two different substrates
Popis výsledku v původním jazyce
Polyphenolic compounds are largely metabolized in the colon by microflora in plethora of small metabolites. These metabolites are largely absorbed and can hence have systemic effects. In this paper, the interaction of some parent polyphenolic compounds and metabolites with 2D6 cytochrome was analyzed emloying two different substrates for CYP2D6. Parent compounds were in general more potent inhibitors than metabolites. The inhibition toward both substrates was not equal which means some 2D6 substrate dependence.
Název v anglickém jazyce
Inhibitory effects of polyphenols and their colonic metabolites on CYP2D6 enzyme using two different substrates
Popis výsledku anglicky
Polyphenolic compounds are largely metabolized in the colon by microflora in plethora of small metabolites. These metabolites are largely absorbed and can hence have systemic effects. In this paper, the interaction of some parent polyphenolic compounds and metabolites with 2D6 cytochrome was analyzed emloying two different substrates for CYP2D6. Parent compounds were in general more potent inhibitors than metabolites. The inhibition toward both substrates was not equal which means some 2D6 substrate dependence.

Projekt
<a href="/cs/project/EF16_019%2F0000841" target="_blank" >EF16_019/0000841: Zvýšení účinnosti a bezpečnosti léčiv a nutraceutik: moderní metody - nové výzvy</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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