Nanomaterials for direct and indirect immunomodulation: A review of applications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F20%3A10418061" target="_blank" >RIV/00216208:11160/20:10418061 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22310/20:43921616

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=sR54DrV4aX" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=sR54DrV4aX</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ejps.2019.105139" target="_blank" >10.1016/j.ejps.2019.105139</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nanomaterials for direct and indirect immunomodulation: A review of applications

Popis výsledku v původním jazyce

The potential of nanotechnology has been explored throughout fields of medicine and found its application also in immunology. Given the crucial defence role and disseminated character of the immune system, the idea of using its strength in treatment has always been very attractive. Immunomodulation is an optimisation of the immune response both in terms of immunosuppression in autoimmune disorders and immunostimulation in vaccination or cancer immunotherapy. For these purposes, a wide range of nanomaterials has been investigated to influence the immune system directly by their composition itself or indirectly as intact carriers of the active. This review attempts to refer to nanomaterials and drug delivery systems utilised to modulate the immune response. It lists various structural types of nanoparticles discussing their composition and interplay with the immune system. Throughout the literature, both novel and traditional nanoparticles were utilised. The most progressive ones extend beyond the delivery of a single substance moving towards combined drug delivery systems and stimuli-responsive formulations.

Název v anglickém jazyce

Nanomaterials for direct and indirect immunomodulation: A review of applications

Popis výsledku anglicky

The potential of nanotechnology has been explored throughout fields of medicine and found its application also in immunology. Given the crucial defence role and disseminated character of the immune system, the idea of using its strength in treatment has always been very attractive. Immunomodulation is an optimisation of the immune response both in terms of immunosuppression in autoimmune disorders and immunostimulation in vaccination or cancer immunotherapy. For these purposes, a wide range of nanomaterials has been investigated to influence the immune system directly by their composition itself or indirectly as intact carriers of the active. This review attempts to refer to nanomaterials and drug delivery systems utilised to modulate the immune response. It lists various structural types of nanoparticles discussing their composition and interplay with the immune system. Throughout the literature, both novel and traditional nanoparticles were utilised. The most progressive ones extend beyond the delivery of a single substance moving towards combined drug delivery systems and stimuli-responsive formulations.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/GA17-06841S" target="_blank" >GA17-06841S: Studium dynamiky genové regulace nukleárními receptory: porozumění detoxifikačních funkcí a přínos pro optimalizaci farmakoterapie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Pharmaceutical Sciences

ISSN

0928-0987

e-ISSN

—

Svazek periodika

142

Číslo periodika v rámci svazku

January

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

18

Strana od-do

105139

Kód UT WoS článku

000505188900022

EID výsledku v databázi Scopus

2-s2.0-85076473575