A Complex Methodological Approach for the Screening of Efficient and Safe Cobalt Chelators

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F23%3A10471101" target="_blank" >RIV/00216208:11160/23:10471101 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=dL8E.Od5MQ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=dL8E.Od5MQ</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1871530322666221006144449" target="_blank" >10.2174/1871530322666221006144449</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A Complex Methodological Approach for the Screening of Efficient and Safe Cobalt Chelators

Popis výsledku v původním jazyce

Cobalt is an essential trace element, but it can also rarely cause cobalt toxicity. There are no approved selective cobalt chelators. This study aimed to develop a simple and complex methodological approach for screening potential cobalt chelators and evaluating the potential toxicity. A simple spectrophotometric assay employing 1-nitroso-2-naphthol-3,6-disulfonic acid disodium salt (NNDSA) for screening cobalt chelation was standardized and the suitability of the method was verified using four known metal chelators. The potential toxicity of cobalt-chelator complexes was also determined by employing a novel HPLC method with coulometric detection. The effect on erythrocyte haemolysis was tested as well. The described complex methodological approach could serve as a simple yet precise tool for evaluating novel, effective and safe cobalt chelators.

Název v anglickém jazyce

A Complex Methodological Approach for the Screening of Efficient and Safe Cobalt Chelators

Popis výsledku anglicky

Cobalt is an essential trace element, but it can also rarely cause cobalt toxicity. There are no approved selective cobalt chelators. This study aimed to develop a simple and complex methodological approach for screening potential cobalt chelators and evaluating the potential toxicity. A simple spectrophotometric assay employing 1-nitroso-2-naphthol-3,6-disulfonic acid disodium salt (NNDSA) for screening cobalt chelation was standardized and the suitability of the method was verified using four known metal chelators. The potential toxicity of cobalt-chelator complexes was also determined by employing a novel HPLC method with coulometric detection. The effect on erythrocyte haemolysis was tested as well. The described complex methodological approach could serve as a simple yet precise tool for evaluating novel, effective and safe cobalt chelators.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/EF19_073%2F0016935" target="_blank" >EF19_073/0016935: Grantová schémata na UK</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Medicinal Chemistry

ISSN

1573-4064

e-ISSN

1875-6638

Svazek periodika

19

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

13

Strana od-do

495-507

Kód UT WoS článku

001004020500009

EID výsledku v databázi Scopus

2-s2.0-85153881663