Effects of imidazolium ionic liquids on skin barrier lipids - Perspectives for drug delivery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F24%3A10480106" target="_blank" >RIV/00216208:11160/24:10480106 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3vSS9-MkLN" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3vSS9-MkLN</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jcis.2023.12.139" target="_blank" >10.1016/j.jcis.2023.12.139</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of imidazolium ionic liquids on skin barrier lipids - Perspectives for drug delivery

Popis výsledku v původním jazyce

Ionic liquids (ILs) have great potential to facilitate transdermal and topical drug delivery. Here, we investigated the mechanism of action of amphiphilic ILs 1-methyl-3-octylimidazolium bromide (C(8)MIM) and 3-dodecyl-1-methylimidazolium bromide (C(12)MIM) in skin barrier lipid models in comparison to their complex effects in human skin. C(8)MIM incorporated in a skin lipid model was a better permeation enhancer than C(12)MIM for water and model drugs, theophylline and diclofenac. Solid state 2H NMR and X-ray diffraction indicated that both ILs prefer the cholesterol-rich regions in skin lipids without significantly perturbing their lamellar arrangement and that C(8)MIM induces the formation of an isotropic lipid phase to a greater extent compared to C(12)MIM. C(12)MIM applied topically to the lipid model or human skin as a pretreatment was more potent than C(8)MIM. When co-applied with the drugs to human skin, aqueous C(12)MIM was more potent than C(8)MIM in enhancing theophylline permeation, but neither IL affected (even decreased) diclofenac permeation. Thus, the IL&apos;s ability to permeabilize skin lipid barrier is strongly modulated by its ability to reach the site of action and its interactions with drug and solvent. Such an interplay is far from trivial and requires detailed investigation to realize the full potential of ILs.

Název v anglickém jazyce

Effects of imidazolium ionic liquids on skin barrier lipids - Perspectives for drug delivery

Popis výsledku anglicky

Ionic liquids (ILs) have great potential to facilitate transdermal and topical drug delivery. Here, we investigated the mechanism of action of amphiphilic ILs 1-methyl-3-octylimidazolium bromide (C(8)MIM) and 3-dodecyl-1-methylimidazolium bromide (C(12)MIM) in skin barrier lipid models in comparison to their complex effects in human skin. C(8)MIM incorporated in a skin lipid model was a better permeation enhancer than C(12)MIM for water and model drugs, theophylline and diclofenac. Solid state 2H NMR and X-ray diffraction indicated that both ILs prefer the cholesterol-rich regions in skin lipids without significantly perturbing their lamellar arrangement and that C(8)MIM induces the formation of an isotropic lipid phase to a greater extent compared to C(12)MIM. C(12)MIM applied topically to the lipid model or human skin as a pretreatment was more potent than C(8)MIM. When co-applied with the drugs to human skin, aqueous C(12)MIM was more potent than C(8)MIM in enhancing theophylline permeation, but neither IL affected (even decreased) diclofenac permeation. Thus, the IL&apos;s ability to permeabilize skin lipid barrier is strongly modulated by its ability to reach the site of action and its interactions with drug and solvent. Such an interplay is far from trivial and requires detailed investigation to realize the full potential of ILs.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Colloid and Interface Science

ISSN

0021-9797

e-ISSN

1095-7103

Svazek periodika

659

Číslo periodika v rámci svazku

April

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

449-462

Kód UT WoS článku

001154614100001

EID výsledku v databázi Scopus

2-s2.0-85182890369