Alkaloids from the genus Vinca L. (Apocynaceae): a comprehensive biological and structural review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F25%3A10497202" target="_blank" >RIV/00216208:11160/25:10497202 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22330/25:43932845

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=rPm0fcIfbw" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=rPm0fcIfbw</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11101-025-10102-z" target="_blank" >10.1007/s11101-025-10102-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Alkaloids from the genus Vinca L. (Apocynaceae): a comprehensive biological and structural review

Popis výsledku v původním jazyce

This review provides a comprehensive overview of the alkaloids in the genus Vinca L. (Apocynaceae), which is renowned for its rich content of monoterpene indole alkaloids and widespread occurrence in Europe, northwest Africa, and southwest Asia. By consolidating extensive phytochemical and pharmacological research in five phytochemically investigated species within the genus Vinca L., it highlights 202 identified alkaloids - categorized into 20 structural groups - and emphasizes their structural diversity and biological activities. These alkaloids, including notable compounds such as vincamine and reserpine, exhibit a range of biological activities, including antitumor, anti-Alzheimer, antibacterial, and antihypertensive effects. The review also explores biosynthetic pathways, key structural classes (aspidosperma, corynanthe, iboga, yohimbe, strychnos), and the structural and biological complexities surrounding these alkaloids. Additionally, it provides a botanical perspective on Vinca species, underscoring both their historical and current medicinal uses. Overall, the genus Vinca emerges as a valuable source of bioactive compounds, with significant potential for future pharmacognostic and drug development research, particularly in oncology and neurodegenerative diseases.

Název v anglickém jazyce

Alkaloids from the genus Vinca L. (Apocynaceae): a comprehensive biological and structural review

Popis výsledku anglicky

This review provides a comprehensive overview of the alkaloids in the genus Vinca L. (Apocynaceae), which is renowned for its rich content of monoterpene indole alkaloids and widespread occurrence in Europe, northwest Africa, and southwest Asia. By consolidating extensive phytochemical and pharmacological research in five phytochemically investigated species within the genus Vinca L., it highlights 202 identified alkaloids - categorized into 20 structural groups - and emphasizes their structural diversity and biological activities. These alkaloids, including notable compounds such as vincamine and reserpine, exhibit a range of biological activities, including antitumor, anti-Alzheimer, antibacterial, and antihypertensive effects. The review also explores biosynthetic pathways, key structural classes (aspidosperma, corynanthe, iboga, yohimbe, strychnos), and the structural and biological complexities surrounding these alkaloids. Additionally, it provides a botanical perspective on Vinca species, underscoring both their historical and current medicinal uses. Overall, the genus Vinca emerges as a valuable source of bioactive compounds, with significant potential for future pharmacognostic and drug development research, particularly in oncology and neurodegenerative diseases.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/EH22_008%2F0004607" target="_blank" >EH22_008/0004607: Nové technologie pro translační výzkum ve farmaceutických vědách /NETPHARM</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Phytochemistry Reviews

ISSN

1568-7767

e-ISSN

1572-980X

Svazek periodika

24

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

71

Strana od-do

3665-3735

Kód UT WoS článku

001456111700001

EID výsledku v databázi Scopus

2-s2.0-105001793945