Yohimbine stability: analysis of its several decades-old pharmaceutical products and forced degradation study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F25%3A10504904" target="_blank" >RIV/00216208:11160/25:10504904 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/25:10504904

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=R1Zgp4KHsC" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=R1Zgp4KHsC</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00706-025-03352-2" target="_blank" >10.1007/s00706-025-03352-2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Yohimbine stability: analysis of its several decades-old pharmaceutical products and forced degradation study

Popis výsledku v původním jazyce

Yohimbine is an indole alkaloid traditionally used as an aphrodisiac and currently present in various pharmaceutical preparations and herbal dietary supplements. Despite the long history of yohimbine use, stability data for yohimbine in pharmaceutical products remain limited. In this study, we investigated the long-term stability of yohimbine by analyzing five several decades-old pharmaceutical products (three solid formulations and two injectable solutions) dating from the 1930s to the 1970s. Reversed-phase HPLC with UV and tandem mass spectrometric detection was used for compound identification and quantification. Additionally, a forced degradation study was conducted to evaluate the hydrolytic and oxidative stability of yohimbine under various conditions. The results confirm the remarkable stability of yohimbine in solid formulations. In contrast, significant degradation leading to the formation of yohimbinic acid was observed in acidic injectable solutions.

Název v anglickém jazyce

Yohimbine stability: analysis of its several decades-old pharmaceutical products and forced degradation study

Popis výsledku anglicky

Yohimbine is an indole alkaloid traditionally used as an aphrodisiac and currently present in various pharmaceutical preparations and herbal dietary supplements. Despite the long history of yohimbine use, stability data for yohimbine in pharmaceutical products remain limited. In this study, we investigated the long-term stability of yohimbine by analyzing five several decades-old pharmaceutical products (three solid formulations and two injectable solutions) dating from the 1930s to the 1970s. Reversed-phase HPLC with UV and tandem mass spectrometric detection was used for compound identification and quantification. Additionally, a forced degradation study was conducted to evaluate the hydrolytic and oxidative stability of yohimbine under various conditions. The results confirm the remarkable stability of yohimbine in solid formulations. In contrast, significant degradation leading to the formation of yohimbinic acid was observed in acidic injectable solutions.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Monatshefte für Chemie - Chemical Monthly

ISSN

0026-9247

e-ISSN

1434-4475

Svazek periodika

156

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

9

Strana od-do

1027-1035

Kód UT WoS článku

001541712900001

EID výsledku v databázi Scopus

2-s2.0-105012274380