Antiplasmodial Activity of Alkaloids

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F25%3A10505168" target="_blank" >RIV/00216208:11160/25:10505168 - isvavai.cz</a>

Výsledek na webu

<a href="http://link.springer.com/rwe/10.1007/978-3-642-36202-6_277-1" target="_blank" >http://link.springer.com/rwe/10.1007/978-3-642-36202-6_277-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-642-36202-6_277-1" target="_blank" >10.1007/978-3-642-36202-6_277-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Antiplasmodial Activity of Alkaloids

Popis výsledku v původním jazyce

Currently, many drugs used to treat malaria are alkaloids or their synthetic derivatives. The primary natural sources of these compounds are plants and certain marine species. Numerous in vitro and in vivo studies have demonstrated the strong activity of alkaloids against various Plasmodium spp. strains, although cytotoxic effects have also been observed. Several chemical synthesis schemes have been developed to improve their potency, effectiveness, physicochemical properties, and reduce toxicity. Current trends focus on conducting molecular dynamics studies related to different malaria targets, as well as investigating the interaction of alkaloids and their derivatives with different parasite targets. However, significant challenges remain in developing antimalarial drugs that are effective against resistant strains and have reduced toxicity. This chapter discusses some of these challenges and highlights the most notable findings published to date.

Název v anglickém jazyce

Antiplasmodial Activity of Alkaloids

Popis výsledku anglicky

Currently, many drugs used to treat malaria are alkaloids or their synthetic derivatives. The primary natural sources of these compounds are plants and certain marine species. Numerous in vitro and in vivo studies have demonstrated the strong activity of alkaloids against various Plasmodium spp. strains, although cytotoxic effects have also been observed. Several chemical synthesis schemes have been developed to improve their potency, effectiveness, physicochemical properties, and reduce toxicity. Current trends focus on conducting molecular dynamics studies related to different malaria targets, as well as investigating the interaction of alkaloids and their derivatives with different parasite targets. However, significant challenges remain in developing antimalarial drugs that are effective against resistant strains and have reduced toxicity. This chapter discusses some of these challenges and highlights the most notable findings published to date.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Natural Products

ISBN

978-3-642-36202-6

Počet stran výsledku

38

Strana od-do

—

Počet stran knihy

4300

Název nakladatele

Springer

Místo vydání

Berlin

Kód UT WoS kapitoly

—