Comparison of HPLC and CZE methods for analysis of DOTA-like esters - reaction intermediates in synthesis of magnetic resonance contrast agents

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F10%3A10056957" target="_blank" >RIV/00216208:11310/10:10056957 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Comparison of HPLC and CZE methods for analysis of DOTA-like esters - reaction intermediates in synthesis of magnetic resonance contrast agents

Popis výsledku v původním jazyce

RP-HPLC and non-aqueous CZE methods were evaluated for qualitative and quantitative analysis of esterified macrocyclic compounds of the DOTA family (DOTA = 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic: acid). This group of compounds represents important reaction intermediates in synthesis of magnetic resonance contrast agents. Calibration curves in the concentration range from 1.0 x 10(-5) to 1.0 x 10(-3) mol/L were plotted and the experimental data were critically compared in terms of their repeatability, linearity, LOD and LOQ. The optimized methods were successfully applied to the analysis of a real reaction mixture without any further pretreatment.

Název v anglickém jazyce

Comparison of HPLC and CZE methods for analysis of DOTA-like esters - reaction intermediates in synthesis of magnetic resonance contrast agents

Popis výsledku anglicky

RP-HPLC and non-aqueous CZE methods were evaluated for qualitative and quantitative analysis of esterified macrocyclic compounds of the DOTA family (DOTA = 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic: acid). This group of compounds represents important reaction intermediates in synthesis of magnetic resonance contrast agents. Calibration curves in the concentration range from 1.0 x 10(-5) to 1.0 x 10(-3) mol/L were plotted and the experimental data were critically compared in terms of their repeatability, linearity, LOD and LOQ. The optimized methods were successfully applied to the analysis of a real reaction mixture without any further pretreatment.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

—

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Separation Science

ISSN

1615-9306

e-ISSN

—

Svazek periodika

33

Číslo periodika v rámci svazku

4-5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

—

Kód UT WoS článku

000276573800027

EID výsledku v databázi Scopus

—