Chemical and biological evaluation of scandium(III)-polyaminopolycarboxylate complexes as potential PET agents and radiopharmaceuticals

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10104227" target="_blank" >RIV/00216208:11310/11:10104227 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1524/ract.2011.1869" target="_blank" >http://dx.doi.org/10.1524/ract.2011.1869</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1524/ract.2011.1869" target="_blank" >10.1524/ract.2011.1869</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chemical and biological evaluation of scandium(III)-polyaminopolycarboxylate complexes as potential PET agents and radiopharmaceuticals

Popis výsledku v původním jazyce

Scandium isotopes ((44)Sc, (47)Sc) are more available and their properties are convenient for either PET imaging or radiotherapy. To use them in nuclear medicine, ligands forming complexes with a high stability are necessary. Available experimental dataon stability constants for complexes of ligands such as EDTA, DTPA, DOTA, NOTA and TETA with various metal ions have been published. But scandium is the exception since scarce data is available in the literature. Values of stability constants of Sc(III)with the ligands were determined by free-ion selective radiotracer extraction, complemented by (45)Sc NMR and potentiometry data. The thermodynamic stability of the Sc-complexes increases in the order TETA { NOTA { EDTA { DTPA { DOTA. The in vitro stability of the Sc(III) complexes was studied in the presence of hydroxyapatite and rat serum to estimate their in vivo stability. The most stable complex was shown to be Sc-DOTA.

Název v anglickém jazyce

Chemical and biological evaluation of scandium(III)-polyaminopolycarboxylate complexes as potential PET agents and radiopharmaceuticals

Popis výsledku anglicky

Scandium isotopes ((44)Sc, (47)Sc) are more available and their properties are convenient for either PET imaging or radiotherapy. To use them in nuclear medicine, ligands forming complexes with a high stability are necessary. Available experimental dataon stability constants for complexes of ligands such as EDTA, DTPA, DOTA, NOTA and TETA with various metal ions have been published. But scandium is the exception since scarce data is available in the literature. Values of stability constants of Sc(III)with the ligands were determined by free-ion selective radiotracer extraction, complemented by (45)Sc NMR and potentiometry data. The thermodynamic stability of the Sc-complexes increases in the order TETA { NOTA { EDTA { DTPA { DOTA. The in vitro stability of the Sc(III) complexes was studied in the presence of hydroxyapatite and rat serum to estimate their in vivo stability. The most stable complex was shown to be Sc-DOTA.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/MEB021041" target="_blank" >MEB021041: Komplexy scandia s polydentátními ligandy jako potenciální radiofarmaka.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Radiochimica Acta

ISSN

0033-8230

e-ISSN

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Svazek periodika

99

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

653-662

Kód UT WoS článku

000296081600007

EID výsledku v databázi Scopus

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