Eukaryotic pyruvate formate lyase and its activating enzyme were acquired laterally from a firmicute
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10105549" target="_blank" >RIV/00216208:11310/11:10105549 - isvavai.cz</a>
Výsledek na webu
<a href="http://mbe.oxfordjournals.org/content/early/2011/02/03/molbev.msr032.full.pdf+html" target="_blank" >http://mbe.oxfordjournals.org/content/early/2011/02/03/molbev.msr032.full.pdf+html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/molbev/msr032" target="_blank" >10.1093/molbev/msr032</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Eukaryotic pyruvate formate lyase and its activating enzyme were acquired laterally from a firmicute
Popis výsledku v původním jazyce
Most of the major groups of eukaryotes have microbial representatives that thrive in low oxygen conditions. Those that have been studied in detail generate ATP via pathways involving anaerobically functioning enzymes of pyruvate catabolism that are typically absent in aerobic eukaryotes and whose origins remain controversial. Pyruvate formate lyase (Pfl) catalyzes the non-oxidative generation of formate and acetyl-Coenzyme A (CoA) from pyruvate and CoA and is activated by Pfl activating enzyme (Pfla). To clarify the origins of this pathway, we have comprehensively searched for homologs of Pfl and Pfla in publicly available large-scale eukaryotic genomic and cDNA sequencing data, including our own from the anaerobic amoebozoan Mastigamoeba balamuthi. Surprisingly, we find that these enzymes are widely distributed, and are present in diverse facultative or obligate anaerobic eukaryotic representatives of the archaeplastidan, metazoan, amoebozoan, and haptophyte lineages. Using maximum li
Název v anglickém jazyce
Eukaryotic pyruvate formate lyase and its activating enzyme were acquired laterally from a firmicute
Popis výsledku anglicky
Most of the major groups of eukaryotes have microbial representatives that thrive in low oxygen conditions. Those that have been studied in detail generate ATP via pathways involving anaerobically functioning enzymes of pyruvate catabolism that are typically absent in aerobic eukaryotes and whose origins remain controversial. Pyruvate formate lyase (Pfl) catalyzes the non-oxidative generation of formate and acetyl-Coenzyme A (CoA) from pyruvate and CoA and is activated by Pfl activating enzyme (Pfla). To clarify the origins of this pathway, we have comprehensively searched for homologs of Pfl and Pfla in publicly available large-scale eukaryotic genomic and cDNA sequencing data, including our own from the anaerobic amoebozoan Mastigamoeba balamuthi. Surprisingly, we find that these enzymes are widely distributed, and are present in diverse facultative or obligate anaerobic eukaryotic representatives of the archaeplastidan, metazoan, amoebozoan, and haptophyte lineages. Using maximum li
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
—
Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Molecular Biology and Evolution
ISSN
0737-4038
e-ISSN
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Svazek periodika
28
Číslo periodika v rámci svazku
7
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
13
Strana od-do
2087-2099
Kód UT WoS článku
000291756400013
EID výsledku v databázi Scopus
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