Changes of Plasma Obestatin, Ghrelin and NPY in Anorexia and Bulimia Nervosa Patients Before and After a High-Carbohydrate Breakfast
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10105966" target="_blank" >RIV/00216208:11310/11:10105966 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11110/11:10614 RIV/00023761:_____/11:#0000169 RIV/00064165:_____/11:10614
Výsledek na webu
—
DOI - Digital Object Identifier
—
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Changes of Plasma Obestatin, Ghrelin and NPY in Anorexia and Bulimia Nervosa Patients Before and After a High-Carbohydrate Breakfast
Popis výsledku v původním jazyce
Peptides ghrelin, obestatin and neuropeptide Y (NPY) play an important role in regulation of energy homeostasis, the imbalance of which is associated with eating disorders anorexia (AN) and bulimia nervosa (BN). The changes in ghrelin, obestatin and NPYplasma levels were investigated in AN and BN patients after administration of a high-carbohydrate breakfast (1604 kJ). Eight AN women (aged 25.4+-1.9; BMI: 15.8+-0.5), thirteen BN women (aged 22.0+-1.05; BMI: 20.1+-0.41) and eleven healthy women (aged 25.1+-1.16; BMI: 20.9+-0.40) were recruited for the study. We demonstrated increased fasting ghrelin in AN, but not in BN patients, while fasting obestatin and NPY were increased in both AN and BN patients compared to the controls. Administration of high-carbohydrate breakfast induced a similar relative decrease in ghrelin and obestatin plasma levels in all groups, while NPY remained increased in postprandial period in both patient groups. Ghrelin/obestatin ratio was lower in AN and BN com
Název v anglickém jazyce
Changes of Plasma Obestatin, Ghrelin and NPY in Anorexia and Bulimia Nervosa Patients Before and After a High-Carbohydrate Breakfast
Popis výsledku anglicky
Peptides ghrelin, obestatin and neuropeptide Y (NPY) play an important role in regulation of energy homeostasis, the imbalance of which is associated with eating disorders anorexia (AN) and bulimia nervosa (BN). The changes in ghrelin, obestatin and NPYplasma levels were investigated in AN and BN patients after administration of a high-carbohydrate breakfast (1604 kJ). Eight AN women (aged 25.4+-1.9; BMI: 15.8+-0.5), thirteen BN women (aged 22.0+-1.05; BMI: 20.1+-0.41) and eleven healthy women (aged 25.1+-1.16; BMI: 20.9+-0.40) were recruited for the study. We demonstrated increased fasting ghrelin in AN, but not in BN patients, while fasting obestatin and NPY were increased in both AN and BN patients compared to the controls. Administration of high-carbohydrate breakfast induced a similar relative decrease in ghrelin and obestatin plasma levels in all groups, while NPY remained increased in postprandial period in both patient groups. Ghrelin/obestatin ratio was lower in AN and BN com
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
ED - Fyziologie
OECD FORD obor
—
Návaznosti výsledku
Projekt
<a href="/cs/project/NR9158" target="_blank" >NR9158: Postprandiální odpověď ghrelinu a dalších hormonů s účastí v regulaci příjmu potravy u pacientek s anorexia nervosa a bulimia nervosa</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Physiological Research
ISSN
0862-8408
e-ISSN
—
Svazek periodika
60
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
9
Strana od-do
165-173
Kód UT WoS článku
000288563800016
EID výsledku v databázi Scopus
—