DNA Damage and Nucleotide Excision Repair Capacity in Healthy Individuals

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10112359" target="_blank" >RIV/00216208:11310/11:10112359 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/11:00367811 RIV/75010330:_____/11:00009334 RIV/00216208:11130/11:7098 RIV/00064190:_____/11:#0000173

Výsledek na webu

<a href="http://dx.doi.org/10.1002/em.20650" target="_blank" >http://dx.doi.org/10.1002/em.20650</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/em.20650" target="_blank" >10.1002/em.20650</a>

Jazyk výsledku

angličtina

Název v původním jazyce

DNA Damage and Nucleotide Excision Repair Capacity in Healthy Individuals

Popis výsledku v původním jazyce

Interindividual differences in DNA repair capacity (DRC) represent an important source of variability in genome integrity and thus influence health risk. In the last decade, DRC measurement has attracted attention as a potential biomarker in cancer prediction. Aim of the present exploratory study was to characterize the variability in DNA damage and DRC on 100 healthy individuals and to identify biological, lifestyle, or genetic factors modulating these parameters. The ultimate goal was to obtain reference data from cancer-free population, which may constitute background for further investigations on cancer patients. The endogenous DNA damage was measured as a level of DNA single-strand breaks and DRC, specific for nucleotide excision repair (NER), wasevaluated using modified comet assay, following the challenge of peripheral blood mononuclear cells with benzo[a]pyrene diolepoxide. Additionally, genetic polymorphisms in NER genes (XPA, XPC, XPD, and XPG) were assessed. We have observe

Název v anglickém jazyce

DNA Damage and Nucleotide Excision Repair Capacity in Healthy Individuals

Popis výsledku anglicky

Interindividual differences in DNA repair capacity (DRC) represent an important source of variability in genome integrity and thus influence health risk. In the last decade, DRC measurement has attracted attention as a potential biomarker in cancer prediction. Aim of the present exploratory study was to characterize the variability in DNA damage and DRC on 100 healthy individuals and to identify biological, lifestyle, or genetic factors modulating these parameters. The ultimate goal was to obtain reference data from cancer-free population, which may constitute background for further investigations on cancer patients. The endogenous DNA damage was measured as a level of DNA single-strand breaks and DRC, specific for nucleotide excision repair (NER), wasevaluated using modified comet assay, following the challenge of peripheral blood mononuclear cells with benzo[a]pyrene diolepoxide. Additionally, genetic polymorphisms in NER genes (XPA, XPC, XPD, and XPG) were assessed. We have observe

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental and Molecular Mutagenesis

ISSN

0893-6692

e-ISSN

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Svazek periodika

52

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

511-517

Kód UT WoS článku

000294182300001

EID výsledku v databázi Scopus

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