The Role of Mouse Mesenchymal Stem Cells in Differentiation of Naive T-Cells into Anti-Inflammatory Regulatory T-Cell or Proinflammatory Helper T-Cell 17 Population

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10104237" target="_blank" >RIV/00216208:11310/12:10104237 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378050:_____/12:00375938

Výsledek na webu

<a href="http://dx.doi.org/10.1089/scd.2011.0157" target="_blank" >http://dx.doi.org/10.1089/scd.2011.0157</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1089/scd.2011.0157" target="_blank" >10.1089/scd.2011.0157</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The Role of Mouse Mesenchymal Stem Cells in Differentiation of Naive T-Cells into Anti-Inflammatory Regulatory T-Cell or Proinflammatory Helper T-Cell 17 Population

Popis výsledku v původním jazyce

Bone marrow-derived mesenchymal stem cells (MSCs) can produce significant levels of transforming growth factor beta and interleukin-6. These two cytokines represent the key factors that reciprocally regulate the development of naive T-cells into regulatory T-cell (Treg) population or proinflammatory T helper 17 (Th17) cells. We demonstrated that MSCs and their products effectively regulate expression of transcription factors Foxp3 and RORgammat and control the development of Tregs and Th17 cells in a population of alloantigen-activated mouse spleen cells. The immunomodulatory effects of MSCs were more pronounced when these cells were stimulated by addition of anti-inflammatory or proinflammatory cytokines. The results showed that MSCs represent important players that reciprocally regulate the differentiation of naive T-cells into anti-inflammatory Tregs or proinflammatory Th17 cell population and thereby can modulate immunopathological or transplantation reactions.

Název v anglickém jazyce

The Role of Mouse Mesenchymal Stem Cells in Differentiation of Naive T-Cells into Anti-Inflammatory Regulatory T-Cell or Proinflammatory Helper T-Cell 17 Population

Popis výsledku anglicky

Bone marrow-derived mesenchymal stem cells (MSCs) can produce significant levels of transforming growth factor beta and interleukin-6. These two cytokines represent the key factors that reciprocally regulate the development of naive T-cells into regulatory T-cell (Treg) population or proinflammatory T helper 17 (Th17) cells. We demonstrated that MSCs and their products effectively regulate expression of transcription factors Foxp3 and RORgammat and control the development of Tregs and Th17 cells in a population of alloantigen-activated mouse spleen cells. The immunomodulatory effects of MSCs were more pronounced when these cells were stimulated by addition of anti-inflammatory or proinflammatory cytokines. The results showed that MSCs represent important players that reciprocally regulate the differentiation of naive T-cells into anti-inflammatory Tregs or proinflammatory Th17 cell population and thereby can modulate immunopathological or transplantation reactions.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Stem Cells and Development

ISSN

1547-3287

e-ISSN

—

Svazek periodika

21

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

901-910

Kód UT WoS článku

000302222700008

EID výsledku v databázi Scopus

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