The Role of Metallothionein in Oxidative Stress

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10135344" target="_blank" >RIV/00216208:11310/13:10135344 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62156489:43210/13:00199278 RIV/00216208:11130/13:10135344 RIV/00216224:14110/13:00068802 RIV/00216305:26620/13:PU106073 RIV/00064203:_____/13:10135344

Výsledek na webu

<a href="http://dx.doi.org/10.3390/ijms14036044" target="_blank" >http://dx.doi.org/10.3390/ijms14036044</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms14036044" target="_blank" >10.3390/ijms14036044</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The Role of Metallothionein in Oxidative Stress

Popis výsledku v původním jazyce

Free radicals are chemical particles containing one or more unpaired electrons, which may be part of the molecule. They cause the molecule to become highly reactive. The free radicals are also known to play a dual role in biological systems, as they canbe either beneficial or harmful for living systems. It is clear that there are numerous mechanisms participating on the protection of a cell against free radicals. In this review, our attention is paid to metallothioneins (MTs) as small, cysteine-rich and heavy metal-binding proteins, which participate in an array of protective stress responses. The mechanism of the reaction of metallothioneins with oxidants and electrophilic compounds is discussed. Numerous reports indicate that MT protects cells fromexposure to oxidants and electrophiles, which react readily with sulfhydryl groups. Moreover, MT plays a key role in regulation of zinc levels and distribution in the intracellular space. The connections between zinc, MT and cancer are hi

Název v anglickém jazyce

The Role of Metallothionein in Oxidative Stress

Popis výsledku anglicky

Free radicals are chemical particles containing one or more unpaired electrons, which may be part of the molecule. They cause the molecule to become highly reactive. The free radicals are also known to play a dual role in biological systems, as they canbe either beneficial or harmful for living systems. It is clear that there are numerous mechanisms participating on the protection of a cell against free radicals. In this review, our attention is paid to metallothioneins (MTs) as small, cysteine-rich and heavy metal-binding proteins, which participate in an array of protective stress responses. The mechanism of the reaction of metallothioneins with oxidants and electrophilic compounds is discussed. Numerous reports indicate that MT protects cells fromexposure to oxidants and electrophiles, which react readily with sulfhydryl groups. Moreover, MT plays a key role in regulation of zinc levels and distribution in the intracellular space. The connections between zinc, MT and cancer are hi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Molecular Sciences [online]

ISSN

1422-0067

e-ISSN

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Svazek periodika

14

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

23

Strana od-do

6044-6066

Kód UT WoS článku

000316609800090

EID výsledku v databázi Scopus

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