In vivo comparison of DOTA based Ga-68-labelled bisphosphonates for bone imaging in non-tumour models

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10139597" target="_blank" >RIV/00216208:11310/13:10139597 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.nucmedbio.2013.04.012" target="_blank" >http://dx.doi.org/10.1016/j.nucmedbio.2013.04.012</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.nucmedbio.2013.04.012" target="_blank" >10.1016/j.nucmedbio.2013.04.012</a>

Jazyk výsledku

angličtina

Název v původním jazyce

In vivo comparison of DOTA based Ga-68-labelled bisphosphonates for bone imaging in non-tumour models

Popis výsledku v původním jazyce

Bone metastases are a class of cancerous metastases that result from the invasion of a tumor into bone. The solid mass which forms inside the bone is often associated with a constant dull ache and severe spikes in pain, which greatly reduce the quality of life of the patient. Numerous Tc-88m-labeled bisphosphonate functionalised complexes are well established tracers for bone metastases imaging. The objective of this research was to evaluate the pharmacokinetics and behaviour of three DOTA based bisphosphonate functionalised ligands (BPAMD, BPAPD and BPPED), using both Ga-68 mu-PET in vivo imaging and ex vivo biodistribution studies in healthy Wistar rats. The compounds were labelled with Ga-68 in high yields using an ammonium acetate buffer, and subsequently purified using a cation exchange resin. High bone uptake values were observed for all Ga-68-labelled bisphosphonates at 60 minutes p.i. The highest uptake was observed for [Ga-68]BPPED (2.6 +/- 0.3% ID/g) which compares favourably

Název v anglickém jazyce

In vivo comparison of DOTA based Ga-68-labelled bisphosphonates for bone imaging in non-tumour models

Popis výsledku anglicky

Bone metastases are a class of cancerous metastases that result from the invasion of a tumor into bone. The solid mass which forms inside the bone is often associated with a constant dull ache and severe spikes in pain, which greatly reduce the quality of life of the patient. Numerous Tc-88m-labeled bisphosphonate functionalised complexes are well established tracers for bone metastases imaging. The objective of this research was to evaluate the pharmacokinetics and behaviour of three DOTA based bisphosphonate functionalised ligands (BPAMD, BPAPD and BPPED), using both Ga-68 mu-PET in vivo imaging and ex vivo biodistribution studies in healthy Wistar rats. The compounds were labelled with Ga-68 in high yields using an ammonium acetate buffer, and subsequently purified using a cation exchange resin. High bone uptake values were observed for all Ga-68-labelled bisphosphonates at 60 minutes p.i. The highest uptake was observed for [Ga-68]BPPED (2.6 +/- 0.3% ID/g) which compares favourably

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nuclear Medicine and Biology

ISSN

0969-8051

e-ISSN

—

Svazek periodika

40

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

823-830

Kód UT WoS článku

000323087200014

EID výsledku v databázi Scopus

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