Synthesis and Characterization of Ligands and their Gadolinium(III) Complexes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10140214" target="_blank" >RIV/00216208:11310/13:10140214 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/9781118503652.ch3" target="_blank" >http://dx.doi.org/10.1002/9781118503652.ch3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/9781118503652.ch3" target="_blank" >10.1002/9781118503652.ch3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis and Characterization of Ligands and their Gadolinium(III) Complexes

Popis výsledku v původním jazyce

Fundamental requirements for MRI contrast agents (CAs) are high thermodynamic stability and kinetic inertness to assure low toxicity of the CAs, and at least one coordination site available for coordination of a water molecule which is crucial for the contrast enhancement. The clinically approved gadolinium (Gd)(III)-based CAs utilize octadentate ligands. This chapter is dedicated to the synthesis and characterization of ligands and their Gd(III) complexes. First, it talks about the CAs employing linearpolyamine scaffold, and CAs employing cyclen scaffold. Next, the chapter presents representative examples of the polyaminopolycarboxylic bifunctional ligands and conjugation strategies utilized in the frame of MRI research. Description of the ligand syntheses is mostly presented in accordance with the ligand motif. Finally, the chapter describes synthesis and characterization of the lanthanide (Ln)(III) complexes.

Název v anglickém jazyce

Synthesis and Characterization of Ligands and their Gadolinium(III) Complexes

Popis výsledku anglicky

Fundamental requirements for MRI contrast agents (CAs) are high thermodynamic stability and kinetic inertness to assure low toxicity of the CAs, and at least one coordination site available for coordination of a water molecule which is crucial for the contrast enhancement. The clinically approved gadolinium (Gd)(III)-based CAs utilize octadentate ligands. This chapter is dedicated to the synthesis and characterization of ligands and their Gd(III) complexes. First, it talks about the CAs employing linearpolyamine scaffold, and CAs employing cyclen scaffold. Next, the chapter presents representative examples of the polyaminopolycarboxylic bifunctional ligands and conjugation strategies utilized in the frame of MRI research. Description of the ligand syntheses is mostly presented in accordance with the ligand motif. Finally, the chapter describes synthesis and characterization of the lanthanide (Ln)(III) complexes.

Druh

C - Kapitola v odborné knize

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging, Second Edition

ISBN

978-1-119-99176-2

Počet stran výsledku

73

Strana od-do

83-155

Počet stran knihy

496

Název nakladatele

John Wiley & Sons, Ltd

Místo vydání

Chichester, West Sussex PO19 8SQ United Kingdom

Kód UT WoS kapitoly

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