Lanthanide(III) complexes of aminoethyl-DO3A as PARACEST contrast agents based on decoordination of the weakly bound amino group

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10159362" target="_blank" >RIV/00216208:11310/13:10159362 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/13:00058768

Výsledek na webu

<a href="http://dx.doi.org/10.1039/c3dt52031e" target="_blank" >http://dx.doi.org/10.1039/c3dt52031e</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c3dt52031e" target="_blank" >10.1039/c3dt52031e</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Lanthanide(III) complexes of aminoethyl-DO3A as PARACEST contrast agents based on decoordination of the weakly bound amino group

Popis výsledku v původním jazyce

2-Aminoethyl DOTA analogues with unsubstituted (H3L1), monomethylated (H3L2) and dimethylated (H3L3) amino groups were prepared by improved synthetic procedures. Their solid-state structures exhibit an extensive system of intramolecular hydrogen bonds, which is probably present in solution and leads to the rather high value of the last dissociation constant. The stability constants of the H3L1 complexes with La3+ and Gd3+ (20.02 and 22.23, respectively) are similar to those of DO3A and the reduction ofthe pK(A) value of the pendant amino group from 10.51 in the free ligand to 6.06 and 5.83 in the La3+ and Gd3+ complexes, respectively, points to coordination of the amino group. It was confirmed in the solid state structure of the [Yb(L-1)] complex, where disorder between the SA' and TSA' isomers was found. A similar situation is expected in solution, where a fast equilibration among the isomers hampers the unambiguous determination of the isomer ratio in solution. The PARACEST effect w

Název v anglickém jazyce

Lanthanide(III) complexes of aminoethyl-DO3A as PARACEST contrast agents based on decoordination of the weakly bound amino group

Popis výsledku anglicky

2-Aminoethyl DOTA analogues with unsubstituted (H3L1), monomethylated (H3L2) and dimethylated (H3L3) amino groups were prepared by improved synthetic procedures. Their solid-state structures exhibit an extensive system of intramolecular hydrogen bonds, which is probably present in solution and leads to the rather high value of the last dissociation constant. The stability constants of the H3L1 complexes with La3+ and Gd3+ (20.02 and 22.23, respectively) are similar to those of DO3A and the reduction ofthe pK(A) value of the pendant amino group from 10.51 in the free ligand to 6.06 and 5.83 in the La3+ and Gd3+ complexes, respectively, points to coordination of the amino group. It was confirmed in the solid state structure of the [Yb(L-1)] complex, where disorder between the SA' and TSA' isomers was found. A similar situation is expected in solution, where a fast equilibration among the isomers hampers the unambiguous determination of the isomer ratio in solution. The PARACEST effect w

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/GAP207%2F11%2F1437" target="_blank" >GAP207/11/1437: Nové třídy kontrastních látek pro tomografii magnetické rezonance</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Dalton Transactions

ISSN

1477-9226

e-ISSN

—

Svazek periodika

42

Číslo periodika v rámci svazku

44

Stát vydavatele periodika

IN - Indická republika

Počet stran výsledku

13

Strana od-do

15735-15747

Kód UT WoS článku

000326119800027

EID výsledku v databázi Scopus

—