Seroprevalence Rates of BKV, JCV and MCPyV Polyomaviruses in the General Czech Republic Population

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10191360" target="_blank" >RIV/00216208:11310/14:10191360 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023736:_____/14:00010768

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1002/jmv.23841/full" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/jmv.23841/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jmv.23841" target="_blank" >10.1002/jmv.23841</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Seroprevalence Rates of BKV, JCV and MCPyV Polyomaviruses in the General Czech Republic Population

Popis výsledku v původním jazyce

JC and BK polyomaviruses (JCV and BKV) infect humans and can cause severe illnesses in immunocompromised patients. Merkel cell polyomavirus (MCPyV) can be found in skin carcinomas. In this study, we assessed the occurrence of serum antibodies against MCPyV, BKV, and JCV polyomaviruses in a healthy population of the Czech Republic. Serum samples from 991 healthy individuals (age range: 6-64 years) were examined by enzyme-linked immunoassay (ELISA) using virus-like particles (VLPs) based on the major VP1capsid proteins of these viruses. Overall, serum antibodies against MCPyV, JCV, and BKV were found in 63%, 57%, and 69%, respectively, of this population. For all three viruses, these rates were associated with age; the occurrence of antibodies against MCPyV and JCV was highest for those older than 59 years, while the occurrence of antibodies against BKV was highest in those aged 10-19 years and 20-29 years. This is the first large study to determine the seroprevalence rates for BKV, JCV

Název v anglickém jazyce

Seroprevalence Rates of BKV, JCV and MCPyV Polyomaviruses in the General Czech Republic Population

Popis výsledku anglicky

JC and BK polyomaviruses (JCV and BKV) infect humans and can cause severe illnesses in immunocompromised patients. Merkel cell polyomavirus (MCPyV) can be found in skin carcinomas. In this study, we assessed the occurrence of serum antibodies against MCPyV, BKV, and JCV polyomaviruses in a healthy population of the Czech Republic. Serum samples from 991 healthy individuals (age range: 6-64 years) were examined by enzyme-linked immunoassay (ELISA) using virus-like particles (VLPs) based on the major VP1capsid proteins of these viruses. Overall, serum antibodies against MCPyV, JCV, and BKV were found in 63%, 57%, and 69%, respectively, of this population. For all three viruses, these rates were associated with age; the occurrence of antibodies against MCPyV and JCV was highest for those older than 59 years, while the occurrence of antibodies against BKV was highest in those aged 10-19 years and 20-29 years. This is the first large study to determine the seroprevalence rates for BKV, JCV

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP304%2F10%2F1511" target="_blank" >GAP304/10/1511: Studium nového lidského polyomaviru objeveného v carcinomech Merkelových buněk</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Medical Virology

ISSN

0146-6615

e-ISSN

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Svazek periodika

86

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

1560-1568

Kód UT WoS článku

000339486600014

EID výsledku v databázi Scopus

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