Metabolism and functions of copper in brain

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10227351" target="_blank" >RIV/00216208:11310/14:10227351 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.pneurobio.2014.01.002" target="_blank" >http://dx.doi.org/10.1016/j.pneurobio.2014.01.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pneurobio.2014.01.002" target="_blank" >10.1016/j.pneurobio.2014.01.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Metabolism and functions of copper in brain

Popis výsledku v původním jazyce

Copper is an important trace element that is required for essential enzymes. However, due to its redox activity, copper can also lead to the generation of toxic reactive oxygen species. Therefore, cellular uptake, storage as well as export of copper haveto be tightly regulated in order to guarantee sufficient copper supply for the synthesis of copper-containing enzymes but also to prevent copper-induced oxidative stress. In brain, copper is of importance for normal development. In addition, both copperdeficiency as well as excess of copper can seriously affect brain functions. Therefore, this organ possesses ample mechanisms to regulate its copper metabolism. In brain, astrocytes are considered as important regulators of copper homeostasis. Impairments of homeostatic mechanisms in brain copper metabolism have been associated with neurodegeneration in human disorders such as Menkes disease, Wilson's disease and Alzheimer's disease. This review article will summarize the biological fun

Název v anglickém jazyce

Metabolism and functions of copper in brain

Popis výsledku anglicky

Copper is an important trace element that is required for essential enzymes. However, due to its redox activity, copper can also lead to the generation of toxic reactive oxygen species. Therefore, cellular uptake, storage as well as export of copper haveto be tightly regulated in order to guarantee sufficient copper supply for the synthesis of copper-containing enzymes but also to prevent copper-induced oxidative stress. In brain, copper is of importance for normal development. In addition, both copperdeficiency as well as excess of copper can seriously affect brain functions. Therefore, this organ possesses ample mechanisms to regulate its copper metabolism. In brain, astrocytes are considered as important regulators of copper homeostasis. Impairments of homeostatic mechanisms in brain copper metabolism have been associated with neurodegeneration in human disorders such as Menkes disease, Wilson's disease and Alzheimer's disease. This review article will summarize the biological fun

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Progress in Neurobiology

ISSN

0301-0082

e-ISSN

—

Svazek periodika

116

Číslo periodika v rámci svazku

May 2014

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

24

Strana od-do

33-57

Kód UT WoS článku

000336016900003

EID výsledku v databázi Scopus

—