Contrasting patterns of polymorphism and selection in bacterial-sensing toll-like receptor 4 in two house mouse subspecies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10282777" target="_blank" >RIV/00216208:11310/14:10282777 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081766:_____/14:00429660 RIV/67985904:_____/14:00429660 RIV/00216224:14310/14:00094001

Výsledek na webu

<a href="http://dx.doi.org/10.1002/ece3.1137" target="_blank" >http://dx.doi.org/10.1002/ece3.1137</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ece3.1137" target="_blank" >10.1002/ece3.1137</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Contrasting patterns of polymorphism and selection in bacterial-sensing toll-like receptor 4 in two house mouse subspecies

Popis výsledku v původním jazyce

Detailed investigation of variation in genes involved in pathogen recognition is crucial for understanding co-evolutionary processes between parasites and their hosts. Triggering immediate innate response to invading microbes, Toll-like receptors (TLRs)belong presently among the best-studied receptors of vertebrate immunity. TLRs exhibit remarkable interspecific variation and also intra-specific polymorphism is well documented. In humans and laboratory mice, several studies have recently shown that single amino acid substitution may significantly alter receptor function. Unfortunately, data concerning polymorphism in free-living species are still surprisingly scarce. In this study, we analyzed the polymorphism of Toll-like receptor 4 (Tlr4) over the Palearctic range of house mouse (Mus musculus). Our results reveal contrasting evolutionary patterns between the two recently (0.5 million years ago) diverged house mouse subspecies: M. m. domesticus (Mmd) and M. m. musculus (Mmm). Compari

Název v anglickém jazyce

Contrasting patterns of polymorphism and selection in bacterial-sensing toll-like receptor 4 in two house mouse subspecies

Popis výsledku anglicky

Detailed investigation of variation in genes involved in pathogen recognition is crucial for understanding co-evolutionary processes between parasites and their hosts. Triggering immediate innate response to invading microbes, Toll-like receptors (TLRs)belong presently among the best-studied receptors of vertebrate immunity. TLRs exhibit remarkable interspecific variation and also intra-specific polymorphism is well documented. In humans and laboratory mice, several studies have recently shown that single amino acid substitution may significantly alter receptor function. Unfortunately, data concerning polymorphism in free-living species are still surprisingly scarce. In this study, we analyzed the polymorphism of Toll-like receptor 4 (Tlr4) over the Palearctic range of house mouse (Mus musculus). Our results reveal contrasting evolutionary patterns between the two recently (0.5 million years ago) diverged house mouse subspecies: M. m. domesticus (Mmd) and M. m. musculus (Mmm). Compari

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EG - Zoologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA206%2F08%2F0640" target="_blank" >GA206/08/0640: Immunogenetické studium hybridní zóny myší domácích</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Ecology And Evolution

ISSN

2045-7758

e-ISSN

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Svazek periodika

4

Číslo periodika v rámci svazku

14

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

2931-2944

Kód UT WoS článku

000340146300010

EID výsledku v databázi Scopus

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