Compartmentalization in Hybrid Metallacarborane Nanoparticles Formed by Block Copolymers with Star-Like Architecture

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10282820" target="_blank" >RIV/00216208:11310/14:10282820 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389013:_____/14:00438197

Výsledek na webu

<a href="http://pubs.acs.org/doi/pdf/10.1021/mz5004757" target="_blank" >http://pubs.acs.org/doi/pdf/10.1021/mz5004757</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/mz5004757" target="_blank" >10.1021/mz5004757</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Compartmentalization in Hybrid Metallacarborane Nanoparticles Formed by Block Copolymers with Star-Like Architecture

Popis výsledku v původním jazyce

One strategy to control the morphology of hybrid polymeric nanostructures is the proper selection of macromolecule architecture. We prepared metallacarborane-rich nanoparticles by interaction of doublehydrophilic block copolymers consisting of both poly(2-alkyl oxazolines) and poly(ethylene oxide) blocks with cobaltabisdicarbollide anion in physiological saline. The inner structure of the hybrid nanoparticles was studied by cryo-TEM, light scattering, SAXS, NMR, and ITC. Although the thermodynamics of diblock and star-like systems are almost identical, the macromolecular architecture has a great impact on the size and inner morphology of the nanoparticles. While hybrid nanoparticles formed by linear diblock copolymers are homogeneous, resembling gel-like nanospheres, the star-like shape of 4-arm block copolymers with PEO blocks in central parts of macromolecules leads to distinct compartmentalization. Because metallacarboranes are promising species in medicine, the studied nanoparticle

Název v anglickém jazyce

Compartmentalization in Hybrid Metallacarborane Nanoparticles Formed by Block Copolymers with Star-Like Architecture

Popis výsledku anglicky

One strategy to control the morphology of hybrid polymeric nanostructures is the proper selection of macromolecule architecture. We prepared metallacarborane-rich nanoparticles by interaction of doublehydrophilic block copolymers consisting of both poly(2-alkyl oxazolines) and poly(ethylene oxide) blocks with cobaltabisdicarbollide anion in physiological saline. The inner structure of the hybrid nanoparticles was studied by cryo-TEM, light scattering, SAXS, NMR, and ITC. Although the thermodynamics of diblock and star-like systems are almost identical, the macromolecular architecture has a great impact on the size and inner morphology of the nanoparticles. While hybrid nanoparticles formed by linear diblock copolymers are homogeneous, resembling gel-like nanospheres, the star-like shape of 4-arm block copolymers with PEO blocks in central parts of macromolecules leads to distinct compartmentalization. Because metallacarboranes are promising species in medicine, the studied nanoparticle

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS Macro Letters

ISSN

2161-1653

e-ISSN

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Svazek periodika

3

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

1151-1155

Kód UT WoS článku

000345264800011

EID výsledku v databázi Scopus

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