Protein evolution of Toll-like receptors 4, 5 and 7 within Galloanserae birds

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10287597" target="_blank" >RIV/00216208:11310/14:10287597 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081766:_____/14:00434859

Výsledek na webu

<a href="http://dx.doi.org/10.1186/s12711-014-0072-6" target="_blank" >http://dx.doi.org/10.1186/s12711-014-0072-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12711-014-0072-6" target="_blank" >10.1186/s12711-014-0072-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Protein evolution of Toll-like receptors 4, 5 and 7 within Galloanserae birds

Popis výsledku v původním jazyce

Background: Toll-like receptors (TLR) are essential activators of the innate part of the vertebrate immune system. In this study, we analysed the interspecific variability of three TLR (bacterial-sensing TLR4 and TLR5 and viral-sensing TLR7) within the Galloanserae bird clade, investigated their phylogeny, assessed their structural conservation and estimated site-specific selection pressures. Results: Physiochemical properties varied according to the TLR analysed, mainly with regards to the surface electrostatic potential distribution. The predicted ligand-binding features (mainly in TLR4 and TLR5) differed between the avian proteins and their fish and mammalian counterparts, but also varied within the Galloanserae birds. We identified 20 positively selected sites in the three TLR, among which several are topologically close to ligand-binding sites reported for mammalian and fish TLR. We described 26, 28 and 25 evolutionarily non-conservative sites in TLR4, TLR5 and TLR7, respectively.

Název v anglickém jazyce

Protein evolution of Toll-like receptors 4, 5 and 7 within Galloanserae birds

Popis výsledku anglicky

Background: Toll-like receptors (TLR) are essential activators of the innate part of the vertebrate immune system. In this study, we analysed the interspecific variability of three TLR (bacterial-sensing TLR4 and TLR5 and viral-sensing TLR7) within the Galloanserae bird clade, investigated their phylogeny, assessed their structural conservation and estimated site-specific selection pressures. Results: Physiochemical properties varied according to the TLR analysed, mainly with regards to the surface electrostatic potential distribution. The predicted ligand-binding features (mainly in TLR4 and TLR5) differed between the avian proteins and their fish and mammalian counterparts, but also varied within the Galloanserae birds. We identified 20 positively selected sites in the three TLR, among which several are topologically close to ligand-binding sites reported for mammalian and fish TLR. We described 26, 28 and 25 evolutionarily non-conservative sites in TLR4, TLR5 and TLR7, respectively.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EG - Zoologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Genetics, Selection, Evolution

ISSN

0999-193X

e-ISSN

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Svazek periodika

46

Číslo periodika v rámci svazku

72

Stát vydavatele periodika

FR - Francouzská republika

Počet stran výsledku

12

Strana od-do

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Kód UT WoS článku

000347079900001

EID výsledku v databázi Scopus

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