Glioma-Associated Proteases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10288629" target="_blank" >RIV/00216208:11310/14:10288629 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/14:10288629

Výsledek na webu

<a href="http://link.springer.com/chapter/10.1007/978-3-7091-1431-5_12" target="_blank" >http://link.springer.com/chapter/10.1007/978-3-7091-1431-5_12</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-7091-1431-5_12" target="_blank" >10.1007/978-3-7091-1431-5_12</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Glioma-Associated Proteases

Popis výsledku v původním jazyce

Proteolytic enzymes constitute 2-3 % of all known human genes and represent an important tool for the control of the biological functions of proteins. During gliomagenesis, the complex regulation of proteases in transformed and stromal cells is impairedas a result of several factors, and proteases critically contribute to the hallmarks of gliomas. Proteins regulated by proteases include components of the extracellular matrix, local mediators, cell surface receptors, ion channels and adhesion molecules,cytoskeletal proteins, components of the intracellular sig- naling cascades, and regulators of the cell cycle. Via the proteolytic modifications of these substrates and/or by non-proteolytic mechanisms, the extracellular as well as intracellular proteases contribute to the increased invasiveness of glioma cells, promote the self-renewal and proliferation of glioma stem-like cells, and facilitate tumor neovascularization. The role of proteases in glioma progression is therefore multiface

Název v anglickém jazyce

Glioma-Associated Proteases

Popis výsledku anglicky

Proteolytic enzymes constitute 2-3 % of all known human genes and represent an important tool for the control of the biological functions of proteins. During gliomagenesis, the complex regulation of proteases in transformed and stromal cells is impairedas a result of several factors, and proteases critically contribute to the hallmarks of gliomas. Proteins regulated by proteases include components of the extracellular matrix, local mediators, cell surface receptors, ion channels and adhesion molecules,cytoskeletal proteins, components of the intracellular sig- naling cascades, and regulators of the cell cycle. Via the proteolytic modifications of these substrates and/or by non-proteolytic mechanisms, the extracellular as well as intracellular proteases contribute to the increased invasiveness of glioma cells, promote the self-renewal and proliferation of glioma stem-like cells, and facilitate tumor neovascularization. The role of proteases in glioma progression is therefore multiface

Druh

C - Kapitola v odborné knize

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Glioma Cell Biology

ISBN

978-3-7091-1430-8

Počet stran výsledku

79

Strana od-do

317-395

Počet stran knihy

468

Název nakladatele

Springer

Místo vydání

Vídeň

Kód UT WoS kapitoly

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