Regulation of 11 beta-Hydroxysteroid Dehydrogenase Type 1 and 7 alpha-Hydroxylase CYP7B1 during Social Stress
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10288761" target="_blank" >RIV/00216208:11310/14:10288761 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/67985823:_____/14:00427743
Výsledek na webu
<a href="http://dx.doi.org/10.1371/journal.pone.0089421" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0089421</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0089421" target="_blank" >10.1371/journal.pone.0089421</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Regulation of 11 beta-Hydroxysteroid Dehydrogenase Type 1 and 7 alpha-Hydroxylase CYP7B1 during Social Stress
Popis výsledku v původním jazyce
11 beta-hydroxysteroid dehydrogenase type 1 (11HSD1) is an enzyme that amplifies intracellular glucocorticoid concentration by the conversion of inert glucocorticoids to active forms and is involved in the interconversion of 7-oxo- and 7-hydroxysteroids,which can interfere with the activation of glucocorticoids. The presence of 11HSD1 in the structures of the hypothalamic-pituitary-adrenal (HPA) axis suggests that this enzyme might play a role in the regulation of HPA output. Here we show that the exposure of Fisher 344 rats to mild social stress based on the resident-intruder paradigm increased the expression of 11HSD1 and CYP7B1, an enzyme that catalyzes 7-hydroxylation of steroids. We found that social behavioral profile of intruders was significantly decreased whereas their plasma levels of corticosterone were increased more than in residents. The stress did not modulate 11HSD1 in the HPA axis (paraventricular nucleus, pituitary, adrenal cortex) but selectively upregulated 11HSD1
Název v anglickém jazyce
Regulation of 11 beta-Hydroxysteroid Dehydrogenase Type 1 and 7 alpha-Hydroxylase CYP7B1 during Social Stress
Popis výsledku anglicky
11 beta-hydroxysteroid dehydrogenase type 1 (11HSD1) is an enzyme that amplifies intracellular glucocorticoid concentration by the conversion of inert glucocorticoids to active forms and is involved in the interconversion of 7-oxo- and 7-hydroxysteroids,which can interfere with the activation of glucocorticoids. The presence of 11HSD1 in the structures of the hypothalamic-pituitary-adrenal (HPA) axis suggests that this enzyme might play a role in the regulation of HPA output. Here we show that the exposure of Fisher 344 rats to mild social stress based on the resident-intruder paradigm increased the expression of 11HSD1 and CYP7B1, an enzyme that catalyzes 7-hydroxylation of steroids. We found that social behavioral profile of intruders was significantly decreased whereas their plasma levels of corticosterone were increased more than in residents. The stress did not modulate 11HSD1 in the HPA axis (paraventricular nucleus, pituitary, adrenal cortex) but selectively upregulated 11HSD1
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
ED - Fyziologie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GAP303%2F10%2F0969" target="_blank" >GAP303/10/0969: Lokální metabolismus glukokortikoidů a neuroendokrinní regulace během stresu</a><br>
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
PLoS ONE
ISSN
1932-6203
e-ISSN
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Svazek periodika
9
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
12
Strana od-do
—
Kód UT WoS článku
000331717900093
EID výsledku v databázi Scopus
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