Adaptation to continuous and intermittent normobaric hypoxia is associated with similar alterations in the myocardial ?-adrenergic signaling system

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10290404" target="_blank" >RIV/00216208:11310/14:10290404 - isvavai.cz</a>

Výsledek na webu

<a href="http://cardiologyacademicpress.com/soap/pdf/delme_2504_540f7d146d1a78.95763896.pdf" target="_blank" >http://cardiologyacademicpress.com/soap/pdf/delme_2504_540f7d146d1a78.95763896.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Adaptation to continuous and intermittent normobaric hypoxia is associated with similar alterations in the myocardial ?-adrenergic signaling system

Popis výsledku v původním jazyce

Adaptation to chronic hypoxia can protect the heart against acute ischemic injury under certain conditions. However, the molecular mechanisms engaged in adaptive changes of the heart are still not well understood. Here we assessed the effects of adaptation to 3-week continuous (CNH) or intermittent normobaric hypoxia (INH; 23 h hypoxia followed by 1 h reoxygenation) on ?-adrenergic signaling in the rat myocardium. Exposure to both regimens of hypoxia resulted in loss of body weight and marked right ventricular (RV) hypertrophy. Whereas there was no significant change in ?-adrenoceptors (?-ARs) in the left ventricles (LV), the total number of these receptors was reduced by about 25% in RV preparations from animals adapted to hypoxia. Discrimination of ?-AR receptor subtypes indicated that the diminution of these receptors was largerly attributable to the loss of ?1-ARs. Chronic hypoxia did not substantially influence the expression of the dominant isoforms of myocardial adenylyl cyclase

Název v anglickém jazyce

Adaptation to continuous and intermittent normobaric hypoxia is associated with similar alterations in the myocardial ?-adrenergic signaling system

Popis výsledku anglicky

Adaptation to chronic hypoxia can protect the heart against acute ischemic injury under certain conditions. However, the molecular mechanisms engaged in adaptive changes of the heart are still not well understood. Here we assessed the effects of adaptation to 3-week continuous (CNH) or intermittent normobaric hypoxia (INH; 23 h hypoxia followed by 1 h reoxygenation) on ?-adrenergic signaling in the rat myocardium. Exposure to both regimens of hypoxia resulted in loss of body weight and marked right ventricular (RV) hypertrophy. Whereas there was no significant change in ?-adrenoceptors (?-ARs) in the left ventricles (LV), the total number of these receptors was reduced by about 25% in RV preparations from animals adapted to hypoxia. Discrimination of ?-AR receptor subtypes indicated that the diminution of these receptors was largerly attributable to the loss of ?1-ARs. Chronic hypoxia did not substantially influence the expression of the dominant isoforms of myocardial adenylyl cyclase

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP303%2F12%2F1162" target="_blank" >GAP303/12/1162: Interakce mezi dlouhodobými formami kardioprotekce vyvolané adaptací na chronickou hypoxii a pravidelnou fyzickou zátěží.</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Experimental and Clinical Cardiology

ISSN

1205-6626

e-ISSN

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Svazek periodika

20

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

CA - Kanada

Počet stran výsledku

15

Strana od-do

4871-4885

Kód UT WoS článku

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EID výsledku v databázi Scopus

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