Complex 3D Models to Study Drug Targeting of Invadopodia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10291255" target="_blank" >RIV/00216208:11310/14:10291255 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.2174/2212697X113016660003" target="_blank" >http://dx.doi.org/10.2174/2212697X113016660003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/2212697X113016660003" target="_blank" >10.2174/2212697X113016660003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Complex 3D Models to Study Drug Targeting of Invadopodia

Popis výsledku v původním jazyce

Metastasis is the main cause of death in cancer patients, and in spite of its significance, it is still incompletely understood. In order for cancer to be metastatic, it must undergo a sequence of events, termed as the metastatic cascade. The ability ofcancer cells to migrate and invade surrounding tissue is a critical step in the metastasis and is often associated with the formation of specific cellular structures called invadopodia. Invadopodia are actin-based protrusions of tumour cells or transformed cells critically involved in protease secretion and targeting, and cytoskeletal rearrangements enabling cellular invasion. Anti-invadopodia therapy is a possible new field in anti-metastatic treatment. We propose here a novel model for drug discoveryof anti-invadopodial compounds based on large scale screening of invadopodia formation in 2D setting followed by validation of the results in complex 3D matrices such as dermis-based matrix.

Název v anglickém jazyce

Complex 3D Models to Study Drug Targeting of Invadopodia

Popis výsledku anglicky

Metastasis is the main cause of death in cancer patients, and in spite of its significance, it is still incompletely understood. In order for cancer to be metastatic, it must undergo a sequence of events, termed as the metastatic cascade. The ability ofcancer cells to migrate and invade surrounding tissue is a critical step in the metastasis and is often associated with the formation of specific cellular structures called invadopodia. Invadopodia are actin-based protrusions of tumour cells or transformed cells critically involved in protease secretion and targeting, and cytoskeletal rearrangements enabling cellular invasion. Anti-invadopodia therapy is a possible new field in anti-metastatic treatment. We propose here a novel model for drug discoveryof anti-invadopodial compounds based on large scale screening of invadopodia formation in 2D setting followed by validation of the results in complex 3D matrices such as dermis-based matrix.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EA - Morfologické obory a cytologie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Cancer Drugs [online]

ISSN

2212-6988

e-ISSN

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Svazek periodika

1

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

5

Strana od-do

85-89

Kód UT WoS článku

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EID výsledku v databázi Scopus

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