Pharmacokinetics of pure silybin diastereoisomers and identification of their metabolites in rat plasma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10293143" target="_blank" >RIV/00216208:11310/15:10293143 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388971:_____/15:00455575 RIV/61989592:15310/15:33156734 RIV/61989592:15110/15:33156734

Výsledek na webu

<a href="http://ac.els-cdn.com/S1756464615000936/1-s2.0-S1756464615000936-main.pdf?_tid=77d12fbe-cbd5-11e4-87fe-00000aab0f02&acdnat=1426508022_b98c29875a4f6e921ea42f6f51a04bf6" target="_blank" >http://ac.els-cdn.com/S1756464615000936/1-s2.0-S1756464615000936-main.pdf?_tid=77d12fbe-cbd5-11e4-87fe-00000aab0f02&acdnat=1426508022_b98c29875a4f6e921ea42f6f51a04bf6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jff.2015.02.031" target="_blank" >10.1016/j.jff.2015.02.031</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pharmacokinetics of pure silybin diastereoisomers and identification of their metabolites in rat plasma

Popis výsledku v původním jazyce

The flavonolignan silybin (isolated from the fruits of the milk thistle, Silybum marianum), is a mixture of two diastereoisomers and has anticancer, chemoprotective, hepatoprotective and dermatoprotective properties. This compound is largely used in various functional foods, nutraceutics and food supplements. The pharmacokinetic profiles of optically pure silybins (silybin A and silybin B) were monitored in rat plasma after the intragastric administration (200 mg.kgMINUS SIGN 1 of body weight) of each diastereoisomer. Free (unconjugated) and total (free + conjugated) silybins were monitored for 6 hours by HPLC-PDA.The metabolic profiles of each silybin diastereoisomer were completely different. Our results clearly demonstrate that silybin B (Cmax = 14.50 g.mLMINUS SIGN 1,Tmax = 2.6 hours,T1/2 = 2.9 hours; total silybin B) was absorbed faster and in a substantially higher amount than silybin A (Cmax = 1.05 g.mLMINUS SIGN 1, Tmax = 3.9 hours, T1/2 = 2.2 hours; total silybin A). The oral

Název v anglickém jazyce

Pharmacokinetics of pure silybin diastereoisomers and identification of their metabolites in rat plasma

Popis výsledku anglicky

The flavonolignan silybin (isolated from the fruits of the milk thistle, Silybum marianum), is a mixture of two diastereoisomers and has anticancer, chemoprotective, hepatoprotective and dermatoprotective properties. This compound is largely used in various functional foods, nutraceutics and food supplements. The pharmacokinetic profiles of optically pure silybins (silybin A and silybin B) were monitored in rat plasma after the intragastric administration (200 mg.kgMINUS SIGN 1 of body weight) of each diastereoisomer. Free (unconjugated) and total (free + conjugated) silybins were monitored for 6 hours by HPLC-PDA.The metabolic profiles of each silybin diastereoisomer were completely different. Our results clearly demonstrate that silybin B (Cmax = 14.50 g.mLMINUS SIGN 1,Tmax = 2.6 hours,T1/2 = 2.9 hours; total silybin B) was absorbed faster and in a substantially higher amount than silybin A (Cmax = 1.05 g.mLMINUS SIGN 1, Tmax = 3.9 hours, T1/2 = 2.2 hours; total silybin A). The oral

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Functional Foods

ISSN

1756-4646

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

April 2015

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

570-580

Kód UT WoS článku

000364500000057

EID výsledku v databázi Scopus

2-s2.0-84926355452