Nanofibers for drug delivery - incorporation and release of model molecules, influence of molecular weight and polymer structure

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10311984" target="_blank" >RIV/00216208:11310/15:10311984 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389013:_____/15:00447826

Výsledek na webu

<a href="http://dx.doi.org/10.3762/bjnano.6.198" target="_blank" >http://dx.doi.org/10.3762/bjnano.6.198</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3762/bjnano.6.198" target="_blank" >10.3762/bjnano.6.198</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nanofibers for drug delivery - incorporation and release of model molecules, influence of molecular weight and polymer structure

Popis výsledku v původním jazyce

Nanofibers were prepared from polycaprolactone, polylactide and polyvinyl alcohol using Nanospider (TM) technology. Polyethylene glycols with molecular weights of 2 000, 6 000, 10 000 and 20 000 g/mol, which can be used to moderate the release profile ofincorporated pharmacologically active compounds, served as model molecules. They were terminated by aromatic isocyanate and incorporated into the nanofibers. The release of these molecules into an aqueous environment was investigated. The influences ofthe molecular length and chemical composition of the nanofibers on the release rate and the amount of released polyethylene glycols were evaluated. Longer molecules released faster, as evidenced by a significantly higher amount of released molecules after 72 hours. However, the influence of the chemical composition of nanofibers was even more distinct - the highest amount of polyethylene glycol molecules released from polyvinyl alcohol nanofibers, the lowest amount from polylactide nanof

Název v anglickém jazyce

Nanofibers for drug delivery - incorporation and release of model molecules, influence of molecular weight and polymer structure

Popis výsledku anglicky

Nanofibers were prepared from polycaprolactone, polylactide and polyvinyl alcohol using Nanospider (TM) technology. Polyethylene glycols with molecular weights of 2 000, 6 000, 10 000 and 20 000 g/mol, which can be used to moderate the release profile ofincorporated pharmacologically active compounds, served as model molecules. They were terminated by aromatic isocyanate and incorporated into the nanofibers. The release of these molecules into an aqueous environment was investigated. The influences ofthe molecular length and chemical composition of the nanofibers on the release rate and the amount of released polyethylene glycols were evaluated. Longer molecules released faster, as evidenced by a significantly higher amount of released molecules after 72 hours. However, the influence of the chemical composition of nanofibers was even more distinct - the highest amount of polyethylene glycol molecules released from polyvinyl alcohol nanofibers, the lowest amount from polylactide nanof

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Beilstein Journal of Nanotechnology

ISSN

2190-4286

e-ISSN

—

Svazek periodika

6

Číslo periodika v rámci svazku

September

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

7

Strana od-do

1939-1945

Kód UT WoS článku

000361791300001

EID výsledku v databázi Scopus

2-s2.0-84949683603