The genomic and phenotypic diversity of Schizosaccharomyces pombe

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10314143" target="_blank" >RIV/00216208:11310/15:10314143 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1038/ng.3215" target="_blank" >http://dx.doi.org/10.1038/ng.3215</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/ng.3215" target="_blank" >10.1038/ng.3215</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The genomic and phenotypic diversity of Schizosaccharomyces pombe

Popis výsledku v původním jazyce

Natural variation within species reveals aspects of genome evolution and function. The fission yeast Schizosaccharomyces pombe is an important model for eukaryotic biology, but researchers typically use one standard laboratory strain. To extend the usefulness of this model, we surveyed the genomic and phenotypic variation in 161 natural isolates. We sequenced the genomes of all strains, finding moderate genetic diversity (pi = 3 x 10(-3) substitutions/site) and weak global population structure. We estimate that dispersal of S. pombe began during human antiquity (similar to 340 BCE), and ancestors of these strains reached the Americas at similar to 1623 CE. We quantified 74 traits, finding substantial heritable phenotypic diversity. We conducted 223 genomewide association studies, with 89 traits showing at least one association. The most significant variant for each trait explained 22% of the phenotypic variance on average, with indels having larger effects than SNPs. This analysis repr

Název v anglickém jazyce

The genomic and phenotypic diversity of Schizosaccharomyces pombe

Popis výsledku anglicky

Natural variation within species reveals aspects of genome evolution and function. The fission yeast Schizosaccharomyces pombe is an important model for eukaryotic biology, but researchers typically use one standard laboratory strain. To extend the usefulness of this model, we surveyed the genomic and phenotypic variation in 161 natural isolates. We sequenced the genomes of all strains, finding moderate genetic diversity (pi = 3 x 10(-3) substitutions/site) and weak global population structure. We estimate that dispersal of S. pombe began during human antiquity (similar to 340 BCE), and ancestors of these strains reached the Americas at similar to 1623 CE. We quantified 74 traits, finding substantial heritable phenotypic diversity. We conducted 223 genomewide association studies, with 89 traits showing at least one association. The most significant variant for each trait explained 22% of the phenotypic variance on average, with indels having larger effects than SNPs. This analysis repr

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

—

Projekt

<a href="/cs/project/GPP305%2F12%2FP040" target="_blank" >GPP305/12/P040: Úloha proteinů CSL v udržování integrity genomu kvasinky Schizosaccharomyces pombe</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature Genetics

ISSN

1061-4036

e-ISSN

—

Svazek periodika

47

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

235-241

Kód UT WoS článku

000350327900013

EID výsledku v databázi Scopus

2-s2.0-84924074129