Cyclam Derivatives with a Bis(phosphinate) or a Phosphinato-Phosphonate Pendant Arm: Ligands for Fast and Efficient Copper(II) Complexation for Nuclear Medical Applications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10315247" target="_blank" >RIV/00216208:11310/15:10315247 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388963:_____/15:00455366 RIV/00216224:14310/15:00081663

Výsledek na webu

<a href="http://dx.doi.org/10.1021/acs.inorgchem.5b01791" target="_blank" >http://dx.doi.org/10.1021/acs.inorgchem.5b01791</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.inorgchem.5b01791" target="_blank" >10.1021/acs.inorgchem.5b01791</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cyclam Derivatives with a Bis(phosphinate) or a Phosphinato-Phosphonate Pendant Arm: Ligands for Fast and Efficient Copper(II) Complexation for Nuclear Medical Applications

Popis výsledku v původním jazyce

Cyclam derivatives bearing one geminal bis(phosphinic acid), -CH2PO2HCH2PO2H2 (H2L1), or phosphinic-phosphonic acid, -CH2PO2HCH2PO3H2 (H3L2), pendant arm were synthesized and studied as potential copper(II) chelators for nuclear medical applications. Theligands showed good selectivity for copper(II) over zinc(II) and nickel(II) ions (log K-CuL = 25.8 and 27.7 for H2L1 and H3L2, respectively). Kinetic study revealed an unusual threestep complex formation mechanism. Quantum-chemical calculations showed small energetic differences between the isomeric complexes of H3L2 compared with analogous data for isomeric complexes of cyclam derivatives with one or two methylphosphonic acid pendant arm(s). Acid-assisted dissociation proved the kinetic inertness of the complexes. Preliminary radiolabeling of H2L1 and H3L2 with Cu-64 was fast and efficient, even at room temperature, giving specific activities of around 70 GBq of Cu-64 per 1 mu mol of the ligand (pH 6.2, 10 min, ca. 90 equiv of the lig

Název v anglickém jazyce

Cyclam Derivatives with a Bis(phosphinate) or a Phosphinato-Phosphonate Pendant Arm: Ligands for Fast and Efficient Copper(II) Complexation for Nuclear Medical Applications

Popis výsledku anglicky

Cyclam derivatives bearing one geminal bis(phosphinic acid), -CH2PO2HCH2PO2H2 (H2L1), or phosphinic-phosphonic acid, -CH2PO2HCH2PO3H2 (H3L2), pendant arm were synthesized and studied as potential copper(II) chelators for nuclear medical applications. Theligands showed good selectivity for copper(II) over zinc(II) and nickel(II) ions (log K-CuL = 25.8 and 27.7 for H2L1 and H3L2, respectively). Kinetic study revealed an unusual threestep complex formation mechanism. Quantum-chemical calculations showed small energetic differences between the isomeric complexes of H3L2 compared with analogous data for isomeric complexes of cyclam derivatives with one or two methylphosphonic acid pendant arm(s). Acid-assisted dissociation proved the kinetic inertness of the complexes. Preliminary radiolabeling of H2L1 and H3L2 with Cu-64 was fast and efficient, even at room temperature, giving specific activities of around 70 GBq of Cu-64 per 1 mu mol of the ligand (pH 6.2, 10 min, ca. 90 equiv of the lig

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Inorganic Chemistry

ISSN

0020-1669

e-ISSN

—

Svazek periodika

54

Číslo periodika v rámci svazku

24

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

16

Strana od-do

11751-11766

Kód UT WoS článku

000367118100020

EID výsledku v databázi Scopus

2-s2.0-84951304849