Multifunctional Amphiphilic Nanoparticles Featuring (Bio)Degradable Core and Dual-Responsive Shell as Biomedical Platforms for Controlled Release
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10315414" target="_blank" >RIV/00216208:11310/15:10315414 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1002/macp.201500235" target="_blank" >http://dx.doi.org/10.1002/macp.201500235</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/macp.201500235" target="_blank" >10.1002/macp.201500235</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Multifunctional Amphiphilic Nanoparticles Featuring (Bio)Degradable Core and Dual-Responsive Shell as Biomedical Platforms for Controlled Release
Popis výsledku v původním jazyce
Multifunctional polymeric platforms combining (bio)degradable and biocompatible, temperature and pH-sensitive entities hold great promise as nanocarriers for targeted drug and gene delivery, and tissue engineering. In this work, preparation and characterization of surfactant-free polyester nanoparticles (NPs) from biobased polyesters poly(butylene sebacate) (PBSE) and poly(butylene sebacate-co-butylene dilinoleate)s (PBSE/PBDL) using nanoprecipitation is reported. This strategy leads to spherical nanosized particles with sizes narrowly distributed in a range of 30-200 nm which is appropriate for internalization by a variety of cells. The effect of molecular parameters and type of solvent used in the nanoprecipitation protocol on the size and shape of produced polyester nanocolloids and their in vitro degradation in PBS solution at 37 degrees C is elucidated by quasi-elastic light scattering (QELS), atomic force microscopy (AFM), transmission electron microscopy (TEM), and size-exclusio
Název v anglickém jazyce
Multifunctional Amphiphilic Nanoparticles Featuring (Bio)Degradable Core and Dual-Responsive Shell as Biomedical Platforms for Controlled Release
Popis výsledku anglicky
Multifunctional polymeric platforms combining (bio)degradable and biocompatible, temperature and pH-sensitive entities hold great promise as nanocarriers for targeted drug and gene delivery, and tissue engineering. In this work, preparation and characterization of surfactant-free polyester nanoparticles (NPs) from biobased polyesters poly(butylene sebacate) (PBSE) and poly(butylene sebacate-co-butylene dilinoleate)s (PBSE/PBDL) using nanoprecipitation is reported. This strategy leads to spherical nanosized particles with sizes narrowly distributed in a range of 30-200 nm which is appropriate for internalization by a variety of cells. The effect of molecular parameters and type of solvent used in the nanoprecipitation protocol on the size and shape of produced polyester nanocolloids and their in vitro degradation in PBS solution at 37 degrees C is elucidated by quasi-elastic light scattering (QELS), atomic force microscopy (AFM), transmission electron microscopy (TEM), and size-exclusio
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CD - Makromolekulární chemie
OECD FORD obor
—
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Macromolecular Chemistry and Physics
ISSN
1022-1352
e-ISSN
—
Svazek periodika
216
Číslo periodika v rámci svazku
23
Stát vydavatele periodika
DE - Spolková republika Německo
Počet stran výsledku
15
Strana od-do
2287-2301
Kód UT WoS článku
000366391600007
EID výsledku v databázi Scopus
2-s2.0-84949536216