Voltammetry at a Hanging Mercury Drop Electrode as a Tool for the Study of the Interaction of Double-stranded DNA with Genotoxic 4-Nitrobiphenyl

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F16%3A10326155" target="_blank" >RIV/00216208:11310/16:10326155 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/elan.201600241" target="_blank" >http://dx.doi.org/10.1002/elan.201600241</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/elan.201600241" target="_blank" >10.1002/elan.201600241</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Voltammetry at a Hanging Mercury Drop Electrode as a Tool for the Study of the Interaction of Double-stranded DNA with Genotoxic 4-Nitrobiphenyl

Popis výsledku v původním jazyce

Differential pulse voltammetry, cyclic voltammetry, alternating current voltammetry, and chronocoulometry at a hanging mercury drop electrode (HMDE) and DNA modified HMDE were used for the study of the interaction of 4-nitrobiphenyl (4-NBP) with double-stranded DNA and for the detection of DNA damage caused by its interaction with 4-NBP. Moreover, the interaction of DNA with intermediates of the 4-NBP reduction and with 4-aminobiphenyl, a metabolite of 4-NBP, was investigated. The mechanism of the electrochemical reduction of 4-NBP was investigated using CV, too. It was found that the reduction of 4-NBP is controlled by both diffusion and adsorption. The rate constant of the reduction and the diffusion coefficient were calculated as well.

Název v anglickém jazyce

Voltammetry at a Hanging Mercury Drop Electrode as a Tool for the Study of the Interaction of Double-stranded DNA with Genotoxic 4-Nitrobiphenyl

Popis výsledku anglicky

Differential pulse voltammetry, cyclic voltammetry, alternating current voltammetry, and chronocoulometry at a hanging mercury drop electrode (HMDE) and DNA modified HMDE were used for the study of the interaction of 4-nitrobiphenyl (4-NBP) with double-stranded DNA and for the detection of DNA damage caused by its interaction with 4-NBP. Moreover, the interaction of DNA with intermediates of the 4-NBP reduction and with 4-aminobiphenyl, a metabolite of 4-NBP, was investigated. The mechanism of the electrochemical reduction of 4-NBP was investigated using CV, too. It was found that the reduction of 4-NBP is controlled by both diffusion and adsorption. The rate constant of the reduction and the diffusion coefficient were calculated as well.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

—

Projekt

<a href="/cs/project/GBP206%2F12%2FG151" target="_blank" >GBP206/12/G151: Centrum nových přístupů k bioanalýze a molekulární diagnostice</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Electroanalysis

ISSN

1040-0397

e-ISSN

—

Svazek periodika

28

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

11

Strana od-do

2760-2770

Kód UT WoS článku

000387891400017

EID výsledku v databázi Scopus

2-s2.0-84978221580