Eu(III) Complex with DO3A-amino-phosphonate Ligand as a Concentration-Independent pH-Responsive Contrast Agent for Magnetic Resonance Spectroscopy (MRS)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F17%3A10360069" target="_blank" >RIV/00216208:11310/17:10360069 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/17:00060342

Výsledek na webu

<a href="http://dx.doi.org/10.1021/acs.inorgchem.6b02749" target="_blank" >http://dx.doi.org/10.1021/acs.inorgchem.6b02749</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.inorgchem.6b02749" target="_blank" >10.1021/acs.inorgchem.6b02749</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Eu(III) Complex with DO3A-amino-phosphonate Ligand as a Concentration-Independent pH-Responsive Contrast Agent for Magnetic Resonance Spectroscopy (MRS)

Popis výsledku v původním jazyce

A new DOTA-like ligand H5do3aNP with a 2-[amino(methylphosphonic acid)]ethyl-coordinating pendant arm was prepared, and its coordinating properties were studied by NMR spectroscopy and potentiometry. The study revealed a rare slow exchange (on the H-1 and P-31 NMR time scale) between protonated and unprotonated complex species with a corresponding acidity constant pK(A) similar to 8.0. This unusually slow time scale associated with protonation is caused by a significant geometric change from square-antiprismatic (SA) arrangement observed for protonated complex SA-[Eu(Hdo(3)aNP)]- to twisted-square-antiprismatic (TSA) arrangement found for deprotonated complex TSA-[Eu(do(3)aNP)](2). This behavior results in simultaneous occurrence of the signals of both species in the 31P NMR spectra at approximately -118 and +70 ppm, respectively. Such an unprecedented difference in the chemical shifts between species differing by a proton is caused by a significant movement of the principal magnetic axis and by a change of phosphorus atom position in the coordination sphere of the central Eu(III) ion (i.e., by relative movement of the phosphorus atom with respect to the principal magnetic axis). It changes the sign of the paramagnetic contribution to the 31P NMR chemical shift. The properties discovered can be employed in the measurement of pH by MRS techniques as presented by proof-of-principle experiments on phantoms.

Název v anglickém jazyce

Eu(III) Complex with DO3A-amino-phosphonate Ligand as a Concentration-Independent pH-Responsive Contrast Agent for Magnetic Resonance Spectroscopy (MRS)

Popis výsledku anglicky

A new DOTA-like ligand H5do3aNP with a 2-[amino(methylphosphonic acid)]ethyl-coordinating pendant arm was prepared, and its coordinating properties were studied by NMR spectroscopy and potentiometry. The study revealed a rare slow exchange (on the H-1 and P-31 NMR time scale) between protonated and unprotonated complex species with a corresponding acidity constant pK(A) similar to 8.0. This unusually slow time scale associated with protonation is caused by a significant geometric change from square-antiprismatic (SA) arrangement observed for protonated complex SA-[Eu(Hdo(3)aNP)]- to twisted-square-antiprismatic (TSA) arrangement found for deprotonated complex TSA-[Eu(do(3)aNP)](2). This behavior results in simultaneous occurrence of the signals of both species in the 31P NMR spectra at approximately -118 and +70 ppm, respectively. Such an unprecedented difference in the chemical shifts between species differing by a proton is caused by a significant movement of the principal magnetic axis and by a change of phosphorus atom position in the coordination sphere of the central Eu(III) ion (i.e., by relative movement of the phosphorus atom with respect to the principal magnetic axis). It changes the sign of the paramagnetic contribution to the 31P NMR chemical shift. The properties discovered can be employed in the measurement of pH by MRS techniques as presented by proof-of-principle experiments on phantoms.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

<a href="/cs/project/GA16-03156S" target="_blank" >GA16-03156S: Samouspořádané polymerní nanostruktury jako bimodální kontrastní látky pro zobrazení magnetickou rezonancí a ultrazvukem</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Inorganic Chemistry

ISSN

0020-1669

e-ISSN

—

Svazek periodika

56

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

2078-2091

Kód UT WoS článku

000394736600035

EID výsledku v databázi Scopus

2-s2.0-85013230695