Amino acids amides of anti-influenza drugs: synthesis and biological activities

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F17%3A10367829" target="_blank" >RIV/00216208:11310/17:10367829 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.bcc.bas.bg/BCC_Volumes/Volume_49_Special_E_2017/BCC-49-E-2017-16-22-Stoykova-3.pdf" target="_blank" >http://www.bcc.bas.bg/BCC_Volumes/Volume_49_Special_E_2017/BCC-49-E-2017-16-22-Stoykova-3.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Amino acids amides of anti-influenza drugs: synthesis and biological activities

Popis výsledku v původním jazyce

Influenza A viruses are amongst the most severe human pathogens leading to high morbidity and mortality worldwide. Due to the high mutation rate and the unpredictable potential for influenza pandemic outbreaks, the development of novel anti-influenza drugs is an undeniably attractive area of research. In the present study amino acid amides of rimantadine and oseltamivir were synthesized and their in vitro antiviral activity against influenza A viruses (A/H3N2) was studied. Results revealed that amide modification of N-alpha- and side chain protected tyrosine, histidine, aspartic- and glutamic acids did not exhibit significant enhancement of the in vitro effect against influenza A virus strain.

Název v anglickém jazyce

Amino acids amides of anti-influenza drugs: synthesis and biological activities

Popis výsledku anglicky

Influenza A viruses are amongst the most severe human pathogens leading to high morbidity and mortality worldwide. Due to the high mutation rate and the unpredictable potential for influenza pandemic outbreaks, the development of novel anti-influenza drugs is an undeniably attractive area of research. In the present study amino acid amides of rimantadine and oseltamivir were synthesized and their in vitro antiviral activity against influenza A viruses (A/H3N2) was studied. Results revealed that amide modification of N-alpha- and side chain protected tyrosine, histidine, aspartic- and glutamic acids did not exhibit significant enhancement of the in vitro effect against influenza A virus strain.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bulgarian Chemical Communications

ISSN

0324-1130

e-ISSN

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Svazek periodika

49

Číslo periodika v rámci svazku

Special Issue E

Stát vydavatele periodika

BG - Bulharská republika

Počet stran výsledku

7

Strana od-do

16-22

Kód UT WoS článku

000418303600004

EID výsledku v databázi Scopus

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