Bile acids: Electrochemical oxidation on bare electrodes after acid-induced dehydration
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F18%3A10368988" target="_blank" >RIV/00216208:11310/18:10368988 - isvavai.cz</a>
Výsledek na webu
<a href="https://doi.org/10.1016/j.elecom.2017.11.024" target="_blank" >https://doi.org/10.1016/j.elecom.2017.11.024</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.elecom.2017.11.024" target="_blank" >10.1016/j.elecom.2017.11.024</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Bile acids: Electrochemical oxidation on bare electrodes after acid-induced dehydration
Popis výsledku v původním jazyce
Bile acids and sterols in general have long been considered practically inactive for direct redox processes. Herein, a novel way of electrochemical oxidation of primary bile acids is reported, involving an initial acid-induced dehydration step, as confirmed by capillary electrophoresis-mass spectrometry, thereby extending the electrochemical activity of the steroid core. Oxidation potentials were found to be ca + 1.2 V vs. Ag/AgNO3 in acetonitrile on boron doped diamond, glassy carbon, and platinum electrodes in a mixed acetonitrile-aqueous medium employing perchloric acid as a chemical reagent, and as a supporting electrolyte for the voltammetric measurements. The chemical step proved to be effective only for primary bile acids, possessing an axial 7 alpha-hydroxyl group, which is a prerequisite for providing a well-developed voltammetric signal. Preliminary results show that other steroids, e.g., cholesterol, can also be oxidized by employing a similar approach.
Název v anglickém jazyce
Bile acids: Electrochemical oxidation on bare electrodes after acid-induced dehydration
Popis výsledku anglicky
Bile acids and sterols in general have long been considered practically inactive for direct redox processes. Herein, a novel way of electrochemical oxidation of primary bile acids is reported, involving an initial acid-induced dehydration step, as confirmed by capillary electrophoresis-mass spectrometry, thereby extending the electrochemical activity of the steroid core. Oxidation potentials were found to be ca + 1.2 V vs. Ag/AgNO3 in acetonitrile on boron doped diamond, glassy carbon, and platinum electrodes in a mixed acetonitrile-aqueous medium employing perchloric acid as a chemical reagent, and as a supporting electrolyte for the voltammetric measurements. The chemical step proved to be effective only for primary bile acids, possessing an axial 7 alpha-hydroxyl group, which is a prerequisite for providing a well-developed voltammetric signal. Preliminary results show that other steroids, e.g., cholesterol, can also be oxidized by employing a similar approach.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10406 - Analytical chemistry
Návaznosti výsledku
Projekt
<a href="/cs/project/GBP206%2F12%2FG151" target="_blank" >GBP206/12/G151: Centrum nových přístupů k bioanalýze a molekulární diagnostice</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Electrochemistry Communications
ISSN
1388-2481
e-ISSN
—
Svazek periodika
86
Číslo periodika v rámci svazku
January
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
5
Strana od-do
99-103
Kód UT WoS článku
000419834400022
EID výsledku v databázi Scopus
2-s2.0-85037137162