Degradation of the opium alkaloids in pharmaceutical relics from the 18th century
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F19%3A10397349" target="_blank" >RIV/00216208:11310/19:10397349 - isvavai.cz</a>
Výsledek na webu
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=j1FL1lO5ie" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=j1FL1lO5ie</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00706-019-02461-z" target="_blank" >10.1007/s00706-019-02461-z</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Degradation of the opium alkaloids in pharmaceutical relics from the 18th century
Popis výsledku v původním jazyce
The opium alkaloids in three historical pharmaceutical relics dated to the eighteenth century were analyzed by HPLC-MS. The conditions of extraction of alkaloids from the sample and their HPLC analysis were optimized. A broad spectrum of opium alkaloids was found and degradation products of papaverine and noscapine were identified. The identity of compounds found was confirmed by MS/MS. For three compounds (methylhydrocotarnine, papaverinol, and papaveraldine) the ESI+-MS/MS fragmentation mechanism has been proposed. The content of five selected opium alkaloids (cotarnine, meconin, morphine, papaverine, and noscapine) was determined in analyzed samples, and the concentration ratio of noscapine and cotarnine was proposed as a marker of the age of a preparation.
Název v anglickém jazyce
Degradation of the opium alkaloids in pharmaceutical relics from the 18th century
Popis výsledku anglicky
The opium alkaloids in three historical pharmaceutical relics dated to the eighteenth century were analyzed by HPLC-MS. The conditions of extraction of alkaloids from the sample and their HPLC analysis were optimized. A broad spectrum of opium alkaloids was found and degradation products of papaverine and noscapine were identified. The identity of compounds found was confirmed by MS/MS. For three compounds (methylhydrocotarnine, papaverinol, and papaveraldine) the ESI+-MS/MS fragmentation mechanism has been proposed. The content of five selected opium alkaloids (cotarnine, meconin, morphine, papaverine, and noscapine) was determined in analyzed samples, and the concentration ratio of noscapine and cotarnine was proposed as a marker of the age of a preparation.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10406 - Analytical chemistry
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Monatshefte für Chemie - Chemical Monthly
ISSN
0026-9247
e-ISSN
—
Svazek periodika
150
Číslo periodika v rámci svazku
9
Stát vydavatele periodika
AT - Rakouská republika
Počet stran výsledku
10
Strana od-do
1593-1602
Kód UT WoS článku
000482907600007
EID výsledku v databázi Scopus
2-s2.0-85070205786