Antiradical activity and bioprediction of o- and p-hydroxybenzoic acid hydrazide derivatives
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F20%3A10417274" target="_blank" >RIV/00216208:11310/20:10417274 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11410/20:10417274
Výsledek na webu
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=.inVghUAsn" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=.inVghUAsn</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.31489/2020Ch1/35-42" target="_blank" >10.31489/2020Ch1/35-42</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Antiradical activity and bioprediction of o- and p-hydroxybenzoic acid hydrazide derivatives
Popis výsledku v původním jazyce
This article provides results of evaluation of synthesized biologically active substances 1-4 antiradical activity according to their ability to interact with the 2,2- diphenyl-1-picrylhydrazyl radical (DPPH center dot). It was found that all synthesized compounds 1-4 have antiradical activity. Pronounced antiradical activity was shown by Nethyl-2-(2-hydroxybenzoyl)hydrazine-carbothioamide (1) (IC50(DPPH) = 12.5 mu Mu) and N-ethyl-2-(4-hydroxybenzoyl)hydrazine-carbothioamide (2) (IC50(DPPH) = 16.7 mu Mu) samples under the conditions of this test system. Activity of N-ethyl-2-(2-hydroxybenzoyl) hydrazinecarbothioamide (1) and N-ethyl-2-(4-hydroxybenzoyl)hydrazinecarbothioamide (2) samples are comparable to activity of known antioxidants. Studied substances 1 and 2 are promising for further advanced research of their antioxidant properties and other types of biological activity. Results of PASS computer system applicability estimation for prediction of biological activity using structural formula as a part of pre-experimental screening are provided. Expected activity of chemical compounds combines physiological activity of initial hydrazides of o- and p-hydroxybenzoic acids as well as components of structural molecule. According to bioprediction data analysis, all compounds can act as inhibitors with a high degree of probability.
Název v anglickém jazyce
Antiradical activity and bioprediction of o- and p-hydroxybenzoic acid hydrazide derivatives
Popis výsledku anglicky
This article provides results of evaluation of synthesized biologically active substances 1-4 antiradical activity according to their ability to interact with the 2,2- diphenyl-1-picrylhydrazyl radical (DPPH center dot). It was found that all synthesized compounds 1-4 have antiradical activity. Pronounced antiradical activity was shown by Nethyl-2-(2-hydroxybenzoyl)hydrazine-carbothioamide (1) (IC50(DPPH) = 12.5 mu Mu) and N-ethyl-2-(4-hydroxybenzoyl)hydrazine-carbothioamide (2) (IC50(DPPH) = 16.7 mu Mu) samples under the conditions of this test system. Activity of N-ethyl-2-(2-hydroxybenzoyl) hydrazinecarbothioamide (1) and N-ethyl-2-(4-hydroxybenzoyl)hydrazinecarbothioamide (2) samples are comparable to activity of known antioxidants. Studied substances 1 and 2 are promising for further advanced research of their antioxidant properties and other types of biological activity. Results of PASS computer system applicability estimation for prediction of biological activity using structural formula as a part of pre-experimental screening are provided. Expected activity of chemical compounds combines physiological activity of initial hydrazides of o- and p-hydroxybenzoic acids as well as components of structural molecule. According to bioprediction data analysis, all compounds can act as inhibitors with a high degree of probability.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10402 - Inorganic and nuclear chemistry
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Bulletin of Karaganda State University, Series chemistry
ISSN
2518-718X
e-ISSN
—
Svazek periodika
Neuveden
Číslo periodika v rámci svazku
97
Stát vydavatele periodika
KZ - Republika Kazachstán
Počet stran výsledku
8
Strana od-do
35-42
Kód UT WoS článku
000523428000004
EID výsledku v databázi Scopus
—