Lineage analysis reveals an endodermal contribution to the vertebrate pituitary

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F20%3A10417567" target="_blank" >RIV/00216208:11310/20:10417567 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=NJ9WW7Ie7p" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=NJ9WW7Ie7p</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1126/science.aba4767" target="_blank" >10.1126/science.aba4767</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Lineage analysis reveals an endodermal contribution to the vertebrate pituitary

Popis výsledku v původním jazyce

Vertebrate sensory organs arise from epithelial thickenings called placodes. Along with neural crest cells, cranial placodes are considered ectodermal novelties that drove evolution of the vertebrate head. The anterior-most placode generates the endocrine lobe [adenohypophysis (ADH)] of the pituitary, a master gland controlling growth, metabolism, and reproduction. In addition to known ectodermal contributions, we use lineage tracing and time-lapse imaging in zebrafish to identify an endodermal contribution to the ADH. Single-cell RNA sequencing of the adult pituitary reveals similar competency of endodermal and ectodermal epithelia to generate all endocrine cell types. Further, endoderm can generate a rudimentary ADH-like structure in the near absence of ectodermal contributions. The fish condition supports the vertebrate pituitary arising through interactions of an ancestral endodermderived proto-pituitary with newly evolved placodal ectoderm.

Název v anglickém jazyce

Lineage analysis reveals an endodermal contribution to the vertebrate pituitary

Popis výsledku anglicky

Vertebrate sensory organs arise from epithelial thickenings called placodes. Along with neural crest cells, cranial placodes are considered ectodermal novelties that drove evolution of the vertebrate head. The anterior-most placode generates the endocrine lobe [adenohypophysis (ADH)] of the pituitary, a master gland controlling growth, metabolism, and reproduction. In addition to known ectodermal contributions, we use lineage tracing and time-lapse imaging in zebrafish to identify an endodermal contribution to the ADH. Single-cell RNA sequencing of the adult pituitary reveals similar competency of endodermal and ectodermal epithelia to generate all endocrine cell types. Further, endoderm can generate a rudimentary ADH-like structure in the near absence of ectodermal contributions. The fish condition supports the vertebrate pituitary arising through interactions of an ancestral endodermderived proto-pituitary with newly evolved placodal ectoderm.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10613 - Zoology

Projekt

<a href="/cs/project/GA19-18634S" target="_blank" >GA19-18634S: Embryonální vývoj bazálních ryb jako unikátní model evoluce hlavy obratlovců</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Science

ISSN

0036-8075

e-ISSN

—

Svazek periodika

370

Číslo periodika v rámci svazku

6515

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

463-466

Kód UT WoS článku

000581077200046

EID výsledku v databázi Scopus

2-s2.0-85094562681